Selected Publications

  1. Blount JR, Libohova K, Marsh GB, Sutton JR, Todi SV (2018). Expression and Regulation of Deubiquitinase-Resistant, Unanchored Ubiquitin Chains in Drosophila. Scientific Reports. doi: 10.1038/s41598-018-26364-x.
  2. Nath SR, Yu Z, Gipson TA, Marsh GB, Yoshidome E, Robins DM, Todi SV, Housman DE, Lieberman AP (2018). Androgen receptor polyglutamine expansion drives age-dependent quality control defects and muscle dysfunction. Journal of Clinical Investigation. doi: 10.1172/JCI9904
  3. Ristic G, Sutton JR, Libohova K, Todi SV (2018). Toxicity and aggregation of the polyglutamine disease protein, ataxin-3 is regulated by its binding to VCP/p97 in Drosophila melanogaster. Neurobiology of Disease. doi: 10.1016/j.nbd.2018.04.01
  4. Murray AS, Varela FA, Hyland TE, Schoenbeck AJ, White JM, Tanabe LM, Todi SV, List K (2017). A novel mechanism regulating type IOI transmembrane serine protease trafficking: Phosphorylation of TMPRSS13 in HAI-1/HAI-2 mediated  cell surface localization. Journal of Biological Chemistry. doi: 10.1074/jbc.M117.775999.  
  5. Das B, Rahagopalan S, Joshi GS, Kandegedara A, Xu L, Lou D, Andersen JK, Todi SV, Dutta A (2017). A novel iron (II) preferring dopamine agonist chelator D-607 significantly suppresses α-Syn- and MPTP-induced toxicities in vivo. Neuropharmacology. doi: 10.1016/j.neuropharm.2017.0019.
  6. Sutton JR, Blount JR, Libohova K, Tsou W-L, Joshi GS, Paulson HL, Costa MDo, Scaglione KM, Todi SV (2017). Interaction of the polyglutamine disease protein ataxin-3 with Rad23 controls its pathogenicity in Drosophila models of Spinocerebellar Ataxia Type 3. Human Molecular Genetics. doi: 10.1093/hmg/ddx039.
  7. Tsou W-L, Qiblawi SH, Hosking RR, Gomez CM, Todi SV (2016). Polyglutamine length-dependent toxicity from α1ACT in Drosophila models of Spinocerebellar Ataxia Type 6. Biology Open. doi:10.1242/bio.02166
  8. Yedlapudi D, Joshi GS, Luo D, Todi SV, Dutta AK (2016). Inhibition of alpha-synuclein aggregation by multifunctional dopamine agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model. Scientific Reports. doi: 10.1038/srep38510. 
  9. Costa Mdo, Ashraf NS, Fischer S, Yang Y, Schappa E, Joshi GS, McQuade T, Dharia RM, Duschavsky M, Ouyang M, Cook D, Sun D, Larsen MJ, Gestwicki JE, Todi SV, Ivanova MI, Paulson HL (2016). Unbiased screen identifies aripiprazole as a modulator of abundance of the polyglutamine disease protein, ataxin-3. Brain. doi: 10.1093/brain/aww228
  10. Chaubal A, Todi SV, Pile LA (2016). Inter-isoform-dependent regulation of master transcriptions regulator SIN3A in Drosophila. Journal of Biological Chemistry. doi: 1074/jbc.C116.724799. 
  11. Ristic G, Guzi E, Tsou W-L, Kanack A, Scaglione KM, Todi SV (2016). USP5 is dispensable for monoubiquitin maintenance in Drosophila. Journal of Biological Chemistry. doi: 10.1074/jbc.M115.703504.
  12. Tsou W-L, Ouyang M, Hosking RR, Sutton JR, Blount JR, Burr AA, Todi SV (2015). The deubiquitinase ataxin-3 requires Rad23 and DnaJ-1 for its neuroprotective role in Drosophila. Neurobiology of Disease. doi: 10.1016/j.nbd.2015.05.010.
  13. Tsou W-L, Hosking RR, Burr AA, Sutton JR, Ouyang M, Du X, Gomez CM, Todi SV (2015). DnaJ-1 and karyopherin α3 suppress degeneration in a new Drosophila model of Spinocerebellar Ataxia Type 6. Human Molecular Genetics, 24(15):4385-96. doi: 10.1093/hmg/ddv174.
  14. Faggiano S, Menon RP, Kelly GP, Todi SV, Scaglione KM, Konarev PV, Svergun DI, Paulson HL, Pastore A (2015). Allosteric regulation of deubiquitylase activity through ubiquitination. Frontiers in Molecular Biosciences, 2(2). doi: 10.3389/fmolb. 2015.00002. 
  15. Blount JR, Tsou W-L, Ristic G, Burr AA, Ouyang M, Galante H, Scaglione KM, Todi SV (2014). Ubiquitin-binding site 2 of ataxin-3 prevents its proteasomal degradation by interacting with Rad23. Nature Communications, 5:4638. doi: 10.1038/ncomms5638.
  16. Burr AA, Tsou W-L, Ristic G, Todi SV (2014). Using membrane-targeted green fluorescent protein to monitor neurotoxic protein-dependent degeneration of Drosophila eyes. Journal of Neuroscience Research, 92(9): 1100-09.