Dr. Maria Bykhovskaia's Laboratory

Synaptic Transmission and Plasticity

Neurons communicate by releasing neuronal transmitters from nerve terminals.  We study the mechanisms and the regulation of the release of neuronal transmitters.
 
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Investigating the synaptic vesicle pools at an active zone employing electron microscopy.
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Paired double-patch recordings of inhibitory synaptic currents from the hippocampal slices of epilepsy susceptible mice. Blue: pyramidal neuron; red: inhibitory basket cell
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Growth of new synaptic boutons observed in vivo in intact Drosophila larvae in response to locomotion. Green: neuronal membrane fluorescent tag (CD8-GFP); red: synaptic vesicle fluorescent tag (SGyrin-mCherry).
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Molecular model of the SNARE protein complex associated with the protein Complexin, mediating the attachment of the synaptic vesicle to the neuronal membrane. Red: Synaptobrevin; Blue: Syntaxin; Green: SNAP25: Magenta: Complexin
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Conformational states of the neuronal calcium sensor Synaptotagmin 1