Dr. Maria Bykhovskaia's Laboratory

Synaptic Transmission and Plasticity

Neurons communicate by releasing neuronal transmitters from nerve terminals.  We study the mechanisms and the regulation of the release of neuronal transmitters.

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Investigating the synaptic vesicle pools at an active zone employing electron microscopy.

 

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Paired double-patch recordings of inhibitory synaptic currents from the hippocampal slices of epilepsy susceptible mice. Blue: pyramidal neuron; red: inhibitory basket cell

 

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Molecular model of the SNARE protein complex associated with the protein Complexin, mediating the attachment of the synaptic vesicle to the neuronal membrane. Red: Synaptobrevin; Blue: Syntaxin; Green: SNAP25: Magenta: Complexin

 

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Conformational states of the neuronal calcium sensor Synaptotagmin 1