Dr. Sokol Todi's Laboratory

 

Spinocerebellar Ataxia Type 3 (SCA3), SCA6, and other misfolding disorders

 

todi1

SCA3.pdf: Using a GFP-based reporter to detect what would otherwise be subtle morphological anomalies caused by pathogenic SCA3 protein.

 

todi5
SCA6.pdf: New fly models to understand degeneration in SCA6.

 

todi3

SCA3-3.pdf: Internal degeneration of fruit fly eyes by different version of the pathogenic SCA3 protein.

 

todi2

SCA3-2.pdf: model of how ataxin-3 is degraded in the cell.

 

 

ubiquitin

Ubiquitin.pdf: New model of how Ubiquitin is recycled in vivo. Dismantle & Reuse is canonical. The other routes were recently proposed by work in our lab.