Research Summary

Dr. Chen’s research is focused on developing quantitative MRI (qMRI) methods of the brain and peripheral nerves. His clinical research interests include neurodegenerative disorders (e.g. Parkinson’s disease and Multiple Sclerosis) and peripheral neuropathies. In collaboration with his colleagues, Dr. Chen has developed a rapid multiparametric qMRI method of the brain referred to as strategically acquired gradient echo (STAGE) imaging. STAGE shortens the time span in studying each patient and still acquires the desired quantitative and qualitative images of the brain. One of his recent contributions to science is the development of a multiparametric qMRI method for peripheral nerves in the leg. The nerve qMRI method has been used to systematically assess the demyelination and axonal loss of peripheral nerves in patients with polyneuropathies. His research laboratory is currently funded by the NIH and Wayne State to develop monitoring biomarkers in patients with inherited peripheral nerve diseases, and diagnostic biomarker signatures to differentiate demyelination from axonal degeneration types of polyneuropathies.