Research

The faculty at Wayne State University School of Medicine is dedicated to bringing to bear the latest advances in basic research to promote a better understanding and to provide innovative new strategies to treat epilepsy. We strive to combine top national expertise in multiple basic and clinical sciences. Our research efforts span from basic mechanisms of synapse development to positron emission tomography and magnetic resonance imaging of brains of patients with epilepsy.

Wayne State University – Detroit Medical Center clinical epilepsy researchers have a long-standing tradition of conducting successful investigator-initiated and industry sponsored clinical trials. Their diverse research interests include management of status epilepticus, unique mechanisms of seizure detection, seizure safety and education, and epilepsy in special populations including pregnant females, elderly and those with other neurological conditions.

Research Support Staff:

Amy Spencer
Clinical Research Coordinator
Contact: 702-812-8129
Email: aspencer@med.wayne.edu
 
Flicia Mada
Research Assistant
Contact: 313-745-4467
 Email: fmada@med.wayne.edu
 
Kalyan Yarraguntla
Research Assistant
Email: kyarragu@med.wayne.edu

 

Ongoing Clinical Trials

1. Fycompa in Routine Clinical Care of Patients With Epilepsy Site PI: Maysaa Basha, M.D. Sponsor: Eisai Co.

2. A Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial With an Open-Label Extension Phase of Perampanel as Adjunctive Treatment in Subjects at Least 2 years of Age With Inadequately Controlled Seizures Associated With Lennox-Gastaut SyndromeSite PI: Deepti Zutshi, M.D.Sponsor: Eisai Co.

3. Efficacy and Safety of Eslicarbazepine Acetate as First Add-on to Levetiracetam or Lamotrigine Monotherapy or as Later Adjunctive Treatment for Subjects with Uncontrolled Partial-onset Seizures: A Multicenter, Open-label, Non-randomized Trial Site PI: Maysaa Basha, M.D. Sponsor: Sunovion

 Active Grants & Awards

1. Epilepsy educational outreach program PI: Deepti Zutshi, M.D. Source: Detroit Medical Center Foundation Awarded Grant: $95,000

2. The sound of seizures: auto-triggered seizure detection PI: Maysaa Basha, M.D Source: Epilepsy Foundation Shark Tank Competition Winner 2017 Awarded Grant: $75,000

3. Effect of seizures in patients with Alzheimer's disease with respect to cognitive progression, imaging and electrographic biomarkers PI: Rohit Marawar, M.D. Source: Albert & Goldye Nelson Grant Awarded Grant: $40,000

4. Safety and analysis educational videos for RNs and EEG techs in Epilepsy Monitoring Unit. PI: Rohit Marawar, M.D. Co-I: Maysaa Basha, M.D. Source: Detroit Receiving Hospital Physician Foundation Awarded Grant: $7,000

5. Cortical Microstructural Changes in African-Americans with Alzheimer's Disease. Co-I: Rohit Marawar, M.D. Source: Michigan Alzheimer's Disease Center Pilot Grant Awarded Grant: $35,000

6. Title: Improving Patient Safety Outcomes and Direct Hospital Costs with the Use of Patient Checklists in Acute Seizure Management. PI: Maysaa Basha, M.D. Source: Blue Cross Blue Shield Michigan Foundation Awarded Grant: $75,000

7. Title: Critical Care EEG Monitoring Research Consortium. A multi-center continuous EEG database for shared EEG based projects. Site PI: Deepti Zutshi Sponsor: Northwestern University, Department of Neurology

Recent Publications

 1. Marawar R, Basha M, Mahulikar A, Desai A, Suchdev K, Shah A. Updates in Refractory Status Epilepticus. Critical care research and practice. 2018.

2. Rao S, Narayanan S, Nanjireddy R, Mittal S, Basha M. Pearls & Oy-sters: Symptomatic cerebral vasospasm on conventional angiography following temporal lobe epilepsy surgery. Neurology. 2017 Jun 6;88(23):e230-

3. Basha MM, Suchdev K, Dhakar M, Kupsky WJ, Mittal S, Shah AK. Acute resective surgery for the treatment of refractory status epilepticus. Neurocritical care. 2017 Dec 1;27(3):370-80.

4. Ali R, Elsayed M, Kaur M, Air E, Mahmood N, Constantinou J, Schwalb J. Use of social media to assess the effectiveness of vagal nerve stimulation in Dravet syndrome: A caregiver's perspective. Journal of the neurological sciences. 2017 Apr 15;375:146-9.

5.  Marawar RA, Yeh HJ, Carnabatu CJ, Stern JM. Functional Mri correlates of resting-state temporal theta and delta Eeg rhythms. Journal of Clinical Neurophysiology. 2017 Jan 1;34(1):69-76

6. Sivakumar S, Zutshi D, Seraji-Bozorgzad N, Shah AK. Effects of Marijuana on Ictal and Interictal EEG Activities in Idiopathic Generalized Epilepsy. Journal of Clinical Neurophysiology. 2017 Jan 1;34(1):e1-4.

 7. Zutshi D. Medication-Induced Seizures and Status Epilepticus. In Continuous EEG Monitoring 2017 (pp. 361-382). Springer, Cham.

8. Basha MM (2017). Episode 4: Acute Resective Surgery for the Treatment of Refractory Status Epilepticus. [podcast] NCS Podcast Series. Neurocritical Care Society.

9. Halford JJ, Arain A, Kalamangalam GP, LaRoche SM, Bonilha L, Basha M, Azar NJ, Kutluay E, Martz GU, Wolf BJ, Waters CG, Dean BC. Characteristics of EEG Interpreters Associated with Higher Inter-rater Agreement. Journal of Clinical Neurophysiology 2017 Mar; 34(2):168-173.

10. Bansal P, Zutshi D, Suchdev K, Azher I, Mohamed W. Alpha 3 ganglionic acetylcholine receptor antibody associated refractory status epilepticus. Seizure-European Journal of Epilepsy. 2016 Feb 1;35:1-3.

11. Mittal S, Barkmeier D, Hua J, Pai D, Fuerst D, Basha M, Loeb J, Shah A. Intracranial EEG analysis in tumor related epilepsy: Evidence of distant epileptic abnormalities. Clinical Neurophysiology 2016 Jan;127(1):238- 44.

12. Desai A, Kherallah R, Szabo C, Marawar R. Gabapentin or Pregabalin Induced Myoclonus: A Case Series and Literature Review. Accepted for publication, Journal of Clinical Neuroscience, Sep 2018.