Yongsheng Chen, PhD

Yongsheng Chen, PhD


Phone: 313-577-2074

Fax: 313 745-4216 (fax)

Yongsheng Chen, PhD

Office Address

Wayne State University School of Medicine
Department of Neurology Suite 8C-UHC
4201 St. Antoine
Detroit, MI 48201

Narrative Bio

Dr. Yongsheng Chen is an Assistant Professor (Research) in Neurology. His research is focused on quantitative magnetic resonance imaging (qMRI) in neurodegenerative disorders and peripheral neuropathies. His research is currently funded by NIH/NINDS.

Academic Rank

Assistant Professor (Research), Department of Neurology


Northeastern University, China — B.S, Computer Engineering, 2002


Northeastern University, China — M.S., Computer Engineering, 2009

Northeastern University, China — Ph.D., Biomedical Engineering, 2018

Prior Appointments

Research Assistant — Radiology, MRI Core, Wayne State University 2015 — 2018

Research Scientist — The MRI Institute for Biomedical Research 2017 — 2018



1. Chen Y+*, Moiseev D+, Kong WY, Bezanovski A, Li J. Automation of Quantifying Axonal Loss in Patients with Peripheral Neuropathies through Deep Learning Derived Muscle Fat Fraction. Journal of Magnetic Resonance Imaging 2021; 53:1539-1549. PMID: 33448058

2. Liu Y+, Li J+, He N, Chen Y*, Jin Z, Yan F*, Haacke EM. Optimizing neuromelanin contrast in the substantia nigra and locus coeruleus using a magnetization transfer contrast prepared 3D gradient recalled echo sequence. NeuroImage 2020; 218:116935. PMID: 32413460 (NeuroImage Front Cover Article)

3. Chen Y, Liu S, Wang Y, Kang Y, Haacke EM*. Strategically Acquired Gradient Echo (STAGE) imaging, part I: Creating enhanced T1 contrast and standardized susceptibility weighted imaging and quantitative susceptibility mapping. Magnetic Resonance Imaging, 2018; 46:130-139. PMID: 29056394

4. Chen Y, Liu S, Buch S, Hu J, Kang Y, Haacke EM*. An interleaved sequence for simultaneous Magnetic Resonance Angiography (MRA), Susceptibility Weighted Imaging (SWI) and Quantitative Susceptibility Mapping (QSM). Magnetic Resonance Imaging, 2018; 47:1-6. PMID: 29154893

5. Chen Y, Liu S, Kang Y, Haacke EM*. A rapid, robust multi-echo phase unwrapping method for quantitative susceptibility mapping (QSM) using strategically acquired gradient echo (STAGE) data acquisition. Proc. SPIE 10573, Medical Imaging 2018; 105732U. DOI: 10.1117/12.2292951

6. Chen Y*, Haacke EM, Li J. Peripheral Nerve Magnetic Resonance Imaging. F1000Res, 2019; 8:1803. PMID: 31700612

7. Chen Y, Haacke EM, Bernitsas E*. Imaging of the spinal cord in multiple sclerosis: past, present, future. Brain Sciences 2020; 10(11):857. PMID: 33202821

8. Pirastru A+, Chen Y+, Pelizzari L, Baglio F, Clerici M, Haacke EM, Lagana MM*. Quantitative Clinical MRI using STrategically Acquired Gradient Echo (STAGE): optimization for 1.5 T scanners and T1 relaxation map validation. European Radiology 2021. PMID:33409790

9. Saba S+, Chen Y+, Maddipati KR, Hackett M, Hu B, Li J*. Demyelination in Hereditary Sensory Neuropathy Type-1C. Annals of Clinical and Translational Neurology 2020; 7(9): 1502-1512. PMID: 32730653

10. Fritz N+, Chen Y+, Waters L, Saba S, Hackett M, Mada FC, Li J*. Fatigue in Patients with Hereditary Neuropathy with Liability to Pressure Palsies. Annals of Clinical and Translational Neurology 2020; 7(8): 1400-1409. PMID: 32856791

11. Jella KP+, Chen Y+, Tu W, Makam S, Beckius S, Hamtaei E, Hsu CCT, Haacke EM*. Quantifying Tissue Properties of the Optic Radiations using Strategically Acquired Gradient Echo Imaging and Enhancing the Contrast using Diamagnetic Susceptibility Weighted Imaging. American Journal of Neuroradiology 2021; 42:285-287. PMID: 33361376.

12. Wang Y, Chen Y, Wu D, Wang Y, Sethi SK, Yang G, Xie H, Xia S, Haacke EM. Strategically Acquired Gradient Echo (STAGE) imaging, part II: Correcting for RF inhomogeneities in estimating T1 and proton density. Magnetic Resonance Imaging, 2018; 46:140-150. PMID: 29061370

13. Haacke EM, Chen Y, Utriainen D, Wu B, Wang Y, Xia S, et al. Strategically Acquired Gradient Echo (STAGE) imaging, part III: Technical Advances and Clinical Applications of A Rapid Multi-Contrast Multi-Parametric Brain Imaging Method. Magnetic Resonance Imaging, 2020; 65:15-26. PMID: 31629075

14. Buch S, Subramanian K, Jella PK, Chen Y, Wu Z, Shah K, Bernitsas E, Ge Y, Haacke EM. Revealing Vascular Abnormalities and Measuring Small Vessel Density in Multiple Sclerosis Lesions using USPIO. NeuroImage-Clinical 2021; 29:102525. PMID: 33338965. PMCID: PMC7750444. doi:10.1016/j.nicl.2020.102525

15. Qu F, Sun T, Chen Y, Yadav BK, Jiang L, Qian Z, Haacke EM. Fetal Brain Tissue Characterization at 1.5T using Strategically Acquired Gradient Echo (STAGE) Imaging. European Radiology 2021. doi:10.1007/s00330-020-07618-7. PMID:33523305.

16. Zhang T, Tang R, Liu S, Chai C, Chen Y, Haacke EM, Xia S. Plaque characteristics of middle cerebral artery assessed using strategically acquired gradient echo (STAGE) and vessel wall MR contribute to misery downstream perfusion in patients with intracranial atherosclerosis. European Radiology 2021; 31:65-75. PMID: 32740814

17. He N, Ghassaban K, Huang P, Jokar M, Wang Y, Cheng Z, Jin Z, Li Y, Sethi SK, He Y, Chen Y, Chen S, Yan F, Haacke EM. Imaging Iron and Neuromelanin Simultaneously Using a Single 3D Magnetization Transfer Sequence: Combining Neuromelanin, Iron and the Nigrosome-1 Sign as Complementary Imaging Biomarkers in Parkinson’s Disease. NeuroImage 2021. DOI: 10.1016/j.neuroimage.2021.117810. PMID: 33524572.

18. Nejad-Davarani SP, Zakariaei N, Chen Y, Haacke EM, Hurst NJ, Siddiqui MS, Schultz LR, Snyder JM, Walbert T, Glide-Hurst C. Rapid Multi-Contrast Brain Imaging on a 0.35T MR-linac. Medical Physics 2020; 47(9): 4064-4076. PMID: 32434276

19. Gharabaghi S, Liu S, Wang Y, Chen Y, Buch S, Jokar M, Wischgoll T, Kashou NH, Zhang C, Wu B, Cheng J, Haacke EM. Multi-Echo Quantitative Susceptibility Mapping for Strategically Acquired Gradient Echo (STAGE) Imaging. Frontiers in Neuroscience 2020; 14:581474. PMID: 33192267. PMCID: PMC7645168.

20. Buch S, Wang Y, Park MG, Jella P, Hu J, Chen Y, Shah K, Ge Y, Haacke EM. Subvoxel Vascular Imaging of the Midbrain Using USPIO-Enhanced MRI. NeuroImage 2020; 220: 117106 PMID: 32615253

21. Tang R, Zhang Q, Chen Y, Liu S, Haacke EM, Chang B, Xia S. Strategically acquired gradient echo (STAGE)-derived MR angiography might be a superior alternative method to time-of-flight MR angiography in visualization of leptomeningeal collaterals. European Radiology 2020; 30:5110-5119. PMID: 32307565

22. Zhou L, Chen Y, Li Y, Gharabaghi S, Chen Y, Sethi SK, Wu Y, Haacke EM. Intracranial iron distribution and quantification in aceruloplasminemia: A case study. Magnetic Resonance Imaging 2020; 70:29-35. PMID:32114188

23. Wang C, Zhang Y, Du J, Huszar IN, Liu S, Chen Y, Buch S, Wu F, Liu Y, Jenkinson M, Hsu CT, Fan Z, Haacke EM, Yang Q. Quantitative Susceptibility Mapping for Characterization of Intraplaque Hemorrhage and Calcification in Carotid Atherosclerotic Disease. J Magn Reson Imaging 2020. doi: 10.1002/jmri.27064. PMID: 32039515

24. He N, Sethi SK, Zhang C, Li Y, Chen Y, Sun B, Yan F, Haacke EM. Visualizing the Lateral habenula using Susceptibility Weighted Imaging and Quantitative Susceptibility Mapping. Magnetic Resonance Imaging, 2020; 65:55-61. PMID: 31655137

25. Liu S, Utriainen D, Chai C, Chen Y, Wang L, Sethi SK, Xia S, Haacke EM. Cerebral microbleed detection using Susceptibility Weighted Imaging and deep learning. Neuroimage, 2019; 198:271-282. PMID: 31121296

26. Buch S, Chen Y, Haacke EM. Susceptibility mapping of the dural sinuses and other superficial veins in the brain. Magnetic Resonance Imaging, 2019; 57:19-27. PMID: 30355528

27. Shen Y, Hu J, Eteer K, Chen Y, Buch S, Alhourani H, Shah K, Jiang Q, Ge Y, Haacke EM. Detecting sub-voxel microvasculature with USPIO-enhanced susceptibility-weighted MRI at 7T. Magnetic Resonance Imaging 2020; 67:90-100. PMID: 31911199

28. Li G, Xu Z, Zhuang A, Chang S, Hou L, Chen Y, Polat M, Wu D. MR Spectroscopy-Detected Change in Marrow Adiposity Is Strongly Correlated to Postmenopausal Breast Cancer Risk. Clinical Breast Cancer, 2017; 17:239-244. PMID: 28188108

29. Liu S, Buch S, Chen Y, Choi HS, Dai Y, Habib C, Hu J, Jung JY, Luo Y, Utriainen D, Wang M, Wu D, Xia S, Haacke EM. Susceptibility-weighted imaging: current status and future directions. NMR Biomed., 2017 vol. 30(4). PMID: 27192086 (NBM Front Cover Article)

30. Haacke EM and Chen Y. Systems and methods for enhancement of resolution for strategically acquired gradient echo (STAGE) imaging. United States Patent, US 0 11,119,170 B1. Date of Patent: Sep. 14, 2021.

My Bibliographyhttps://www.ncbi.nlm.nih.gov/myncbi/yongsheng.chen.2/bibliography/public/


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