Yongsheng Chen

Yongsheng Chen

ys.chen@wayne.edu

Phone: 313-577-2074

Fax: 313 745-4216 (fax)

Yongsheng Chen

Office Address

Department of Neurology

4201 St Antoine Blvd. UHC 8C
Detroit, Michigan 48201

Narrative Bio

Dr. Yongsheng Chen is an Assistant Professor (Research) in Neurology as of December 1, 2018. Dr. Chen received his PhD in Biomedical Engineering from Northeastern University, Shenyang of the Liaoning Province in China.

He was a Research Scientist at the MRI Institute for Biomedical Research from March 2017 until November 2018 where he established STAGE protocols for different vendors’ MRI scanners, distributed them to 21 sites all over the world, and worked closely with these sites to improve, verify and validate the protocols for different neuro-imaging situations.

Dr. Chen was a Research Assistant in the Department of Radiology at Wayne State University from April 2015 until November 2018 where he developed a new simultaneous Magnetic Resonance Angiography and Venography (MRAV) pulse sequence for cerebral and peripheral vessel imaging. He also developed a new quantitative imaging method referred to as “Strategically Acquired Gradient Echo (STAGE) imaging” as well as the post-processing software using MATLAB and Visual Studio C# including the processing of T1 mapping, RF variation mapping, multi-echo Quantitative Susceptibility Mapping (QSM), Susceptibility Weighted Imaging (SWI), and MRAV. Another key development that he contributed to was a new method to image the human retina in vivo at 3T with a spatial resolution less than 100 microns.

Before joining Wayne State University, he worked in the MRI industry for 13 years in software design, MR pulse sequence design, image reconstruction, software verification and validation, software quality control, and 510(k) premarket submissions.
 

Awards & Honors

The ISMRM Summa Cum Laude Merit Award, 2019
The ISMRM Magna Cum Laude Merit Award, 2019
ISMRM Travel Stipend Award, 2019
ISMRM Travel Stipend Award, 2017

Academic Rank

Assistant Professor, Department of Neurology

Other Information

Research Assistant — MR Research Facility, Wayne State University 2015 — 2018
Research Scientist — The MRI Institute for Biomedical Research 2017 — 2018
Software R&D Manager — Liaoning Kampo Medical System Co., Ltd. 2010 — 2015
Senior Software Engineer — Philips and Neusoft Medical Systems Co., Ltd. 2004 — 2010
Software Engineer — Neusoft Medical Systems Co., Ltd. 2001 — 2004

Undergraduate

Northeastern University, China — B.S, Computer Engineering 1998 — 2002

Graduate

Northeastern University, China — M.S., Computer Engineering 2006 — 2009

Northeastern University, China — Ph.D., Biomedical Engineering 2013 — 2018

Specialties

Magnetic Resonance Imaging

Publications

(SELECTED)

Peer-Reviewed Journal Articles:

[1] Y. Chen, EM. Haacke, J. Li. Peripheral Nerve Magnetic Resonance Imaging. F1000Res, 2019; 8:1803 DOI: https://doi.org/10.12688/f1000research.19695.1. PMCID: PMC6820826

[2] Y. Chen, S. Liu, Y. Wang, Y. Kang, and E. M. Haacke, "STrategically Acquired Gradient Echo (STAGE) imaging, part I: Creating enhanced T1 contrast and standardized susceptibility weighted imaging and quantitative susceptibility mapping," Magnetic Resonance Imaging, vol. 46, pp. 130-39, 2018. PMID:29056394

[3] Y. Wang, Y. Chen, D. Wu, Y. Wang, S. K. Sethi, G. Yang, et al., "STrategically Acquired Gradient Echo (STAGE) imaging, part II: Correcting for RF inhomogeneities in estimating T1 and proton density," Magnetic Resonance Imaging, vol. 46, pp. 140-50, 2018. PMID:29061370

[4] EM. Haacke, Y. Chen, D. Utriainen, B. Wu, Y. Wang, S. Xia, et al.. Strategically Acquired Gradient Echo (STAGE) imaging, part III: Technical Advances and Clinical Applications of A Rapid Multi-Contrast Multi-Parametric Brain Imaging Method. Magnetic Resonance Imaging, 2020; 65:15-26. PMID: 31629075

[5] Y. Chen, S. Liu, S. Buch, J. Hu, Y. Kang, and E. M. Haacke, "An interleaved sequence for simultaneous Magnetic Resoannce Angiography (MRA), Susceptibility Weighted Imaging (SWI) and Quantitative Susceptibility Mapping (QSM)," Magnetic Resoannce Imaging, vol. 47, pp. 1-6, 2018. PMID:29154893

[6] S. Liu, D. Utriainen, C. Chai, Y. Chen, L. Wang, SK. Sethi, S. Xia, EM. Haacke. Cerebral microbleed detection using Susceptibility Weighted Imaging and deep learning. Neuroimage, 2019; 198:271-282. PMID: 31121296

[7] N. He, SK. Sethi, C. Zhang, Y. Li, Y. Chen, B. Sun, F. Yan, EM. Haacke. Visualizing the Lateral habenula using Susceptibility Weighted Imaging and Quantitative Susceptibility Mapping. Magnetic Resonance Imaging, 2020; 65:55-61. PMID: 31655137

[8] S. Liu, S. Buch, Y. Chen, H. S. Choi, Y. Dai, C. Habib, et al., "Susceptibility‐weighted imaging: current status and future directions," NMR in Biomedicine, vol. 30, 2017. PMID:27192086

[9] S. Buch, Y. Chen, EM. Haacke. Susceptibility mapping of the dural sinuses and other superficial veins in the brain. Magn Reson Imaging 2019;57:19–27. PMID:30355528

[10] Y. Chen, S. Liu, Y. Kang, and E. M. Haacke, "A rapid, robust multi-echo phase unwrapping method for quantittive susceptibility mapping (QSM) using strategically acquired gradient echo (STAGE) data acquisition," SPIE Medical Imaging, 2018, p. 105732U, doi:10.1117/12.2292951.

Book Chapters:

[1] S. Buch, S. Liu, Y. Chen, K. Ghassaban, and EM. Haacke, "T2*: Susceptibility Weighted Imaging and Quantitative Susceptibility Mapping," in Quantitative MRI of the brain: principles of physical measurement, M. Cercignai, N. G. Dowell, and P. S. Tofts, Eds., 2 ed: CRC Press, 2018.

[2] EM. Haacke, D. Utriainen, S. Buch, and Y. Chen, "MR imaging of intracranial and extracranial veins," in Latest Frontiers of Hemodynamics, Imaging and Treatment of Obstructive Venous Disease, A. Giaquinta, B.-B. Lee, C. Setacci, P. Veroux, and P. Zamboni, Eds., 1st ed: Edizioni Minerva Medica, 2018.

Peer-Reviewed Conference Proceedings:

[1] Chen Y, Lagana M, Xia S, Haacke EM. Strategically Acquired Gradient Echo (STAGE) Imaging for Standardized Multi-Contrast and Quantitative Brain Data Acquisition: Validating T1 mapping and Preliminary Clinical Results. Proc. Intl. Soc. Mag. Reson. Med. 2019; 27:1040. 

[2] Chen Y., Ge Y., Liu S., Hu J., Haacke EM. Imaging the Cerebral Vasculature Using Ferumoxytol Enhanced Susceptibility Weighted Imaging and Quantitative Susceptibility Mapping at 3T. Proc. Intl. Soc. Mag. Reson. Med. 2019; 27:2658.

[3] Chen Y., Xuan Y., Hu J., Juhasz C., Haacke EM. Strategically Acquired Gradient Echo (STAGE) Imaging as a Means for Multi-Contrast Quantitative Pediatric Neuroimaging with Minimized Sedation: A Pilot Study in Sturge-Weber Syndrome. Proc. Intl. Soc. Mag. Reson. Med. 2019; 27:3021.

[4] Zheng J., Chen Y., Gharabaghi S., Haacke EM., Li R., Edalati M., Hastings M., Zayed M. Contrast Free Methods for Vascular Assessment in Lower Extremities of Diabetes. Proc. Intl. Soc. Mag. Reson. Med. 2019; 27:0981.

[5] Wang Y., Chen Y., Utriainen D., Haacke EM. Automatic Segmentation of Deep Grey Matter Structures for Iron Quantification. Proc. Intl. Soc. Mag. Reson. Med. 2019; 27:2715.

[6] Lagana M., Chen Y., Pelizzari L., Cecconi P., Baglio F., Haacke EM. Rapid Protocol for T1 and T2* mapping: Strategically Acquired Gradient Echo (STAGE) at 1.5T MRI. Proc. Intl. Soc. Mag. Reson. Med. 2019; 27:0815.

[7] Liu S., Utriainen D., Chai C., Chen Y., Wang L., Haacke EM. Automatic Detection of Cerebral Microbleeds using Susceptibility Weighted Imaging and Deep Learning. Proc. Intl. Soc. Mag. Reson. Med. 2019; 27:0676.

[8] Qu F., Sun T., Chen Y., Yadav BK., Jiang L., Qian Z., Haacke EM. Fetal Brain Tissue Characterization at 1.5T using STAGE. Proc. Intl. Soc. Mag. Reson. Med. 2019; 27:4071.

[9] Gharabaghi S., Liu S., Wang Y., Chen Y., Wischgoll T., Hashou N., Haacke EM. Structurally Constrained Quantitative Susceptibility Mapping. Proc. Intl. Soc. Mag. Reson. Med. 2019; 27:4928.

[10] He N., Sethi SK., Zhang C., Li Y., Chen Y., Sun B., Yan F., Haacke EM. Visualizing and Characterizing the Habenula with Magnetic Resonance Imaging. Proc. Intl. Soc. Mag. Reson. Med. 2019; 27:2638.

[11] Haacke EM., Bernitsas E., Subramanian K., Utriainen D., Kumar V., Sethi SK., Chen Y., Latif Z., Kumar P., Zheng X., Comley RA., Luo Y. Multi-Parametric White Matter Imaging in Multiple Sclerosis Lesions. Proc. Intl. Soc. Mag. Reson. Med. 2019; 27:3309.

[12] Zakariaei, N., Chen, Y., Nejad-Davarani, S.P., Haacke, E.M. and Glide-Hurst, C.K. Best in Physics (Multidisciplinary): Rapid Multicontrast Brain Imaging at 0.35 t to Facilitate Tumor Response Assessment and Functional Adaptive Radiation Therapy. J Med Phys 2019; 46:e517.

[13] Y. Chen, S. Liu, Y. Kang, and E. M. Haacke, "An Interleaved Sequence for Simultaneous MRA, SWI and QSM," in Int. Soc. Magn. Res. Med. Scientific Meeting, Hawaii, USA, 2017, p1215.

[14] Y. Chen, Y. Song, J. Hu, Y. Ye, Y. Wang, B. A. Berkowitz, et al., "Ultra-High Spatial Resolution Imaging in Vivo of Human Retina at 3T," in Int. Soc. Magn. Res. Med. Scientific Meeting, Hawaii, USA, 2017, p2268.

[15] S. Buch, Y. Chen, and E. M. Haacke, "Susceptibility Mapping of the Dural Sinuses and Other Major Veins in the Brain," in Int. Soc. Magn. Res. Med. Scientific Meeting, Hawaii, USA, 2017

[16] Y. Chen, S. Xia, L. Wang, S. K. Sethi, M. Fawaz, S. Liu, et al., "Automatic Detection of Cerebral
Microbleeds (CMBs) using STrategically Acquired Gradient Echo (STAGE) imaging," in American Society of Neuroradiology (ASNR), Vancouver, BC, Canada, 2018, pp. 211.

[17] P. Huang, J. Lyu, H. Li, Y. Chen, S. Liu, C. Zhang, et al., "Highly Accelerated 3D MR Angiography Using Multi-Channel Blind Deconvolution," in Int. Soc. Magn. Res. Med. Scientific Meeting, Paris, France, 2018, p. p3356.

[18] A. Sun, F. Huang, Y. Wang, W. Xu, Y. Wang, Y. Chen, et al., "Methods to accelerate STAGE: Toward 8 min for Twelve 3D images on 1.5T," in Int. Soc. Magn. Res. Med. Scientific Meeting, Paris, France, 2018, p. p0319.

[19] Y. Wang, F. Huang, W. Xu, T. Li, H. Guo, Y. Chen, et al., "STAGE Imaging at 1.5T: A Rapid Brain Protocol Providing More Images As Well As Quantitative Data," in Int. Soc. Magn. Res. Med. Scientific Meeting, Paris, France, 2018, p. p2750.

[20] N. M. Wiseman, S. Buch, Y. Chen, E. M. Haacke, and Z. Kou, "Magnetic resonance angiography and venography was not useful for correcting underestimated susceptibility measurements of sub-voxel objects on quantitative susceptibility maps," in Int. Soc. Magn. Res. Med. Scientific Meeting, Paris, France, 2018, p1868.

[21] W. Xu, Y. Wang, F. Huang, T. Li, H. Guo, Y. Chen, et al., "A rapid scan for simultaneous MRAV, MRA, tSWI, and QSM on 1.5T," in Int. Soc. Magn. Res. Med. Scientific Meeting, Paris, France, 2018, p1871.

[22] C. Wang, S. Liu, Y. Chen, S. Buch, E. M. Haacke, and Q. Yang, "Intraplaque Hemorrhage and Calcification Detection with Quantitative Susceptibility Mapping," in Int. Soc. Magn. Res. Med. Scientific Meeting, Paris, France, 2018, p0491.

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