Konstantinos Avgerinos, MD, MSc

Konstantinos Avgerinos, MD, MSc

Konstantinos Avgerinos, MD, MSc

Narrative Bio

Dr. Avgerinos is originally from Thessaloniki, Greece. He obtained his Medical Degree and a Master’s in Medical Research Methodology from the Aristotle University School of Medicine. Following his studies, he joined the NIA/NIH as a Post-Doctoral Fellow where he conducted clinical trials exploring the effects of novel metabolic interventions on cognition and biomarkers of brain metabolism. During his time at the NIA, Dr. Avgerinos secured funding to design and conduct a clinical trial on the brain effects of an oral ketone ester in individuals at increased risk of Alzheimer’s. He additionally received the NIH Fellows Award for Research Excellence for presenting results of the effects of empagliflozin on brain metabolism. Dr. Avgerinos is currently a PGY-3 Neurology resident at Wayne State University.

Office Address

Wayne State University School of Medicine
Department of Neurology - 8D UHC
4201 St. Antoine
Detroit, MI 48201
Office Phone: (313) 577-1245
Clinic appointments: (313) 745-4275

Academic Rank

 PGY-3 Resident in Neurology 

Other Information

 Email: konstantinos.avgerinos@wayne.edu

Publications

Selected 

1. Avgerinos, K.I., Manolopoulos, A., Ferrucci, L., Kapogiannis, D. Critical assessment of anti-amyloid-β monoclonal antibodies effects in Alzheimer’s disease: a systematic review and meta-analysis highlighting target engagement and clinical meaningfulness. Sci Rep 14, 25741 (2024). https://doi.org/10.1038/s41598-024-75204-8

2. Kapogiannis, D., Manolopoulos, A., Mullins, R., Avgerinos, K., Delgado-Peraza, F., Mustapic, M., Nogueras-Ortiz, C., Yao, P. J., Pucha, K. A., Brooks, J., Chen, Q., Haas, S. S., Ge, R., Hartnell, L. M., Cookson, M. R., Egan, J. M., Frangou, S., & Mattson, M. P. (2024). Brain responses to intermittent fasting and the healthy living diet in older adults. Cell Metabolism, 36(8), 1668-1678.e5. https://doi.org/10.1016/j.cmet.2024.05.017

3. Ibrahim, M., Kim, P., Marawar, R., Avgerinos, K. I. Bacillus Calmette-Guerin (BCG) Vaccine Impact on Dementia Risk in Bladder Cancer Patients: A Systematic Review and Meta-analysis. J Prev Alz Dis 2024; https://doi.org/10.14283/jpad.2024.94

4. Avgerinos KI, Mullins RJ, Vreones M, Mustapic M, Chen Q, Melvin D, Kapogiannis D, Egan JM. Empagliflozin Induced Ketosis, Upregulated IGF-1/Insulin Receptors and the Canonical Insulin Signaling Pathway in Neurons, and Decreased the Excitatory Neurotransmitter Glutamate in the Brain of Non-Diabetics. Cells. 2022; 11(21):3372. https://doi.org/10.3390/cells11213372

5. Avgerinos K.I., Mullins R.J., Egan J.M., Kapogiannis D. Ketone Ester Effects on Biomarkers of Brain Metabolism and Cognitive Performance in Cognitively Intact Adults ≥ 55 Years Old. A Study Protocol for a Double-Blinded Randomized Controlled Clinical Trial. J Prev Alzheimers Dis (2022). https://doi.org/10.14283/jpad.2022.3

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