Jacob Rube, MD

Jacob Rube, MD

Jacob Rube, MD

Office Address

Wayne State University
School of Medicine
Department of Neurology, Suite 8D- UHC
4201 St. Antoine
Detroit, MI 48201

Schedule an Appointment:  (313) 745-4275
Clinic Fax: (313) 745-4468

Narrative Bio

Jacob Rube MD is an Assistant Professor in Neurology here at Wayne State University. He is also Director of the Residency training program here in neurology. He joined the department on July 1, 2020.  Dr. Rube completed his neurology residency at Northwell Health in Manhasset, NY in 2018.  He served as chief resident in his residency program from July 2017-June 2018. Subsequently, he completed a two year Multiple Sclerosis/Neuroimmunology Fellowship at Wayne State University School of Medicine and Detroit Medical Center. 

Dr. Rube's areas of interest include diagnosis and treatment of both relapsing and progressive Multiple Sclerosis. He also specializes in other autoimmune neurological disorders such including:  NMOSD, MOG antibody disease, Neurosarcoidosis, Myasthenia Gravis, Chronic inflammatory demyelinating polyneuropathy (CIDP),  paraneoplastic disorders, and the neurologic complications of systemic autoimmune disorders such as Lupus and Sjogren's Syndrome. His research interests are clinical aspects of Multiple Sclerosis.

He is board certified in Neurology by the American Board of Psychiatry and Neurology.

Academic Rank

Assistant Professor of Neurology


 Touro College, Brooklyn, NY 2005-2010

Position Title

 Assistant Professor of Neurology
Director, Residency Training Program


Wayne State University School of Medicine, Detroit, MI, 2010- 2014


Staten Island University Hospital, Staten Island, NY, 2014-2015


Northwell Health, Manhasset, NY, 2015-2018


 Neurology, Neuroimmunology, Multiple Sclerosis, Myasthenia Gravis


 Multiple Sclerosis/Neuroimmunology, Wayne State University, Detroit, MI 2018-2019


Research interest:  Multiple Sclerosis/ Neuroimmunology



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