Justin Jeong, PhD

ef5416@wayne.edu

(313) 993-0258

(313) 993-9229 (fax)

Justin Jeong, PhD

Office Address

Translational Imaging Laboratory

University Health Center Suit 4J-B

4201 St. Antoine Blvd. Detroit, MI 48201

Narrative Bio

Jeong-Won Jeong, Ph.D. is a Professor of Pediatrics and Neurology, an accomplished MRI physicist, and a dedicated neuroimaging researcher with a deep commitment to the well-being of sick children. Dr. Jeong's academic journey began with a B.S. in Biomedical Engineering from Yonsei University in Korea. He then pursued his passion further, earning a M.S. in Electrical Engineering and ultimately achieving a doctorate in Biomedical Engineering, both from the University of Southern California. Dr. Jeong embarked on a postdoctoral fellowship at the University of Southern California, where he delved into the realms of Radiology and the Alfred E. Mann Institute for Biomedical Engineering. This pivotal experience fortified his academic foundation and set the stage for his remarkable career.

His professional pursuits are a testament to his unwavering dedication. Dr. Jeong's research and clinical interests revolve around the identification of functional and structural imaging biomarkers, crucial in the diagnosis of complex conditions such as Epilepsy, Developmental Delay, Autism, Sturge Weber Syndrome, and Borderline Personality Disorder.

His impressive body of work encompasses over 80 peer-reviewed full papers, a testament to his commitment to advancing the field. As the principal investigator of an R01 grant project generously funded by the National Institutes of Health, Dr. Jeong is at the forefront of pioneering an advanced diffusion MRI tractography methodology at clinical environment. This methodology has the potential to significantly reduce postoperative deficits in pediatric epilepsy surgery, thereby improving the lives of countless children and their families.

Additionally, Dr. Jeong serves as a Co-Investigator on four additional R01 projects. These endeavors aim to develop cutting-edge multimodal imaging methodologies, combining MRI, PET, and electrocorticography. The goal is to enhance the accuracy of early detection of pediatric neurological disorders, a mission that aligns perfectly with his deep commitment to the welfare of sick children.

Links of Interest

High spatio-temporal resolution dynamic tractography (youtu.be/OVdsOi6RY9A)

High spatio-temporal resolution dynamic tractography with 3D stereotopic rendering (youtu.be/XZa7bJ4dZ8I)

High spatio-temporal resolution dynamic tractography with MRA and MRV (youtu.be/7cV0jM-fIY4)

Academic Rank

Professor

Other Information

Role: Principal Investigator, NIH 2R01NS089659, 02/2015 - 06/2026
Title: Novel DWI Methods to Minimize Postoperative Deficits in Pediatric Epilepsy Surgery
Sponsor Name: National Institute of Neurological Disorders and Stroke (NINDS)
The major goal of this grant study is to utilize deep learning-based diffusion MRI techniques to optimize the surgical margin, predict the postoperative neurocognitive outcome, and determine the specific mechanism of postoperative brain reorganization in children undergoing epilepsy surgery. See details at today.wayne.edu/medicine/news/2022/01/26/mri-physicist-and-team-at-school-of-medicine-net-2-million-grant-that-could-lead-to-freedom-from-seizures-in-pediatric-epilepsy-46831

Undergraduate

Yonsei University, Korea, B.S., 1991

Graduate

University of Southern California, M.S., Biomedical Engineering, 2000

University of Southern California, M.S., Electrical Engineering, 2002

University of Southern California, Ph.D., Biomedical Engineering, 2002

Position Title

Professor of Pediatrics, Neurology and Translational Neuroscience Program

Fellowships

Alfred E. Mann Institute for Biomedical Engineering, 2002-2007

University of Southern California, Radiology, 2004-2009

Specialties

Peidatric multimodal neuroimaging including MRI, PET and ECoG

Interests

Development of functional and structural neuroimaging techniques using diffusion tractography, functional MRI, PET and ECoG in children with epilepsy, developmental delay, autisms, sturge-weber syndrome, and borderline personality disorder.

Advanced brain network analyses using deep learning techniques to quantify and detect brain abnormalities in children.

Presurgical planning computer algorithms to determine whether the seizure focus affects functionally important neural pathways in children with focal epilepsy.

Imaging and genotyping of children with developmental delay to investigate the relation of genotype with MRI phenotype and behavioral deficits in children with developmental delay and impairment.

Publications

Selected Publications (www.ncbi.nlm.nih.gov/myncbi/jeong-won.jeong.1/bibliography/public/)

Sakakura K, Sonoda M, Mitsuhashi T, Kuroda N, Firestone E, O'Hara N, Iwaki H, Lee MH, Jeong JW, Rothermel R, Luat AF, Asano E. Developmental organization of neural dynamics supporting auditory perception. Neuroimage. 2022 Sep;258:119342. doi: 10.1016/j.neuroimage.2022.119342. Epub 2022 May 30. PubMed PMID: 35654375; PubMed Central PMCID: PMC9354710.

Jeong JW, Lee MH, Kuroda N, Sakakura K, OHara N, Juhasz C, Asano E. Multi-Scale Deep Learning of Clinically Acquired Multi-Modal MRI Improves the Localization of Seizure Onset Zone in Children With Drug-Resistant Epilepsy. IEEE J Biomed Health Inform. 2022 Aug 4;PP. doi: 10.1109/JBHI.2022.3196330. [Epub ahead of print] PubMed PMID: 35925854.

O'Hara NB, Lee MH, Juhász C, Asano E, Jeong JW. Diffusion tractography predicts propagated high-frequency activity during epileptic spasms. Epilepsia. 2022 Jul;63(7):1787-1798. doi: 10.1111/epi.17251. Epub 2022 Apr 21. PubMed PMID: 35388455; PubMed Central PMCID: PMC9283246.

Mitsuhashi T, Sonoda M, Firestone E, Sakakura K, Jeong JW, Luat AF, Sood S, Asano E. Temporally and functionally distinct large-scale brain network dynamics supporting task switching. Neuroimage. 2022 Jul 1;254:119126. doi: 10.1016/j.neuroimage.2022.119126. Epub 2022 Mar 22. PubMed PMID: 35331870; PubMed Central PMCID: PMC9173207.

Jeong JW, Lee MH, Fernandes N, Deol S, Mody S, Arslanturk S, Chinnam RB, Tan S. Neonatal encephalopathy prediction of poor outcome with diffusion-weighted imaging connectome and fixel-based analysis. Pediatr Res. 2022 May;91(6):1505-1515. doi: 10.1038/s41390-021-01550-2. Epub 2021 May 8. PubMed PMID: 33966055; PubMed Central PMCID: PMC9053106.

Johnson EL, Yin Q, O'Hara NB, Tang L, Jeong JW, Asano E, Ofen N. Dissociable oscillatory theta signatures of memory formation in the developing brain. Curr Biol. 2022 Apr 11;32(7):1457-1469.e4. doi: 10.1016/j.cub.2022.01.053. Epub 2022 Feb 15. PubMed PMID: 35172128; PubMed Central PMCID: PMC9007830.

Mitsuhashi T, Sonoda M, Sakakura K, Jeong JW, Luat AF, Sood S, Asano E. Dynamic tractography-based localization of spike sources and animation of spike propagations. Epilepsia. 2021 Oct;62(10):2372-2384. doi: 10.1111/epi.17025. Epub 2021 Jul 29. PubMed PMID: 34324194; PubMed Central PMCID: PMC8487933.

Jeong JW, Lee MH, O'Hara N, Juhász C, Asano E. Prediction of baseline expressive and receptive language function in children with focal epilepsy using diffusion tractography-based deep learning network. Epilepsy Behav. 2021 Apr;117:107909. doi: 10.1016/j.yebeh.2021.107909. Epub 2021 Mar 16. PubMed PMID: 33740493; PubMed Central PMCID: PMC8035310.

Banerjee S, Dong M, Lee MH, O'Hara N, Juhasz C, Asano E, Jeong JW. Deep Relational Reasoning for the Prediction of Language Impairment and Postoperative Seizure Outcome Using Preoperative DWI Connectome Data of Children With Focal Epilepsy. IEEE Trans Med Imaging. 2021 Mar;40(3):793-804. doi: 10.1109/TMI.2020.3036933. Epub 2021 Mar 2. PubMed PMID: 33166251; PubMed Central PMCID: PMC8544001.

Lee MH, O'Hara N, Sonoda M, Kuroda N, Juhasz C, Asano E, Dong M, Jeong JW. Novel Deep Learning Network Analysis of Electrical Stimulation Mapping-Driven Diffusion MRI Tractography to Improve Preoperative Evaluation of Pediatric Epilepsy. IEEE Trans Biomed Eng. 2020 Nov;67(11):3151-3162. doi: 10.1109/TBME.2020.2977531. Epub 2020 Mar 2. PubMed PMID: 32142416; PubMed Central PMCID: PMC7598774.

Silverstein BH, Asano E, Sugiura A, Sonoda M, Lee MH, Jeong JW. Dynamic tractography: Integrating cortico-cortical evoked potentials and diffusion imaging. Neuroimage. 2020 Jul 15;215:116763. doi: 10.1016/j.neuroimage.2020.116763. Epub 2020 Apr 12. PubMed PMID: 32294537; PubMed Central PMCID: PMC7292749.

Sugiura A, Silverstein BH, Jeong JW, Nakai Y, Sonoda M, Motoi H, Asano E. Four-dimensional map of direct effective connectivity from posterior visual areas. Neuroimage. 2020 Apr 15;210:116548. doi: 10.1016/j.neuroimage.2020.116548. Epub 2020 Jan 17. PubMed PMID: 31958582; PubMed Central PMCID: PMC7054169.

Lee MH, O'Hara NB, Behen ME, Jeong JW. Altered efficiency of white matter connections for language function in children with language disorder. Brain Lang. 2020 Apr;203:104743. doi: 10.1016/j.bandl.2020.104743. Epub 2020 Jan 28. PubMed PMID: 32004807; PubMed Central PMCID: PMC9022213.

Lee MH, O'Hara NB, Motoi H, Luat AF, Juhász C, Sood S, Asano E, Jeong JW. Novel diffusion tractography methodology using Kalman filter prediction to improve preoperative benefit-risk analysis in pediatric epilepsy surgery. J Neurosurg Pediatr. 2019 Jul 5;:1-13. doi: 10.3171/2019.4.PEDS1994. [Epub ahead of print] PubMed PMID: 31277057; PubMed Central PMCID: PMC9080971.

Xu H, Dong M, Lee MH, OrHara N, Asano E, Jeong JW. Objective Detection of Eloquent Axonal Pathways to Minimize Postoperative Deficits in Pediatric Epilepsy Surgery using Diffusion Tractography and Convolutional Neural Networks. IEEE Trans Med Imaging. 2019 Feb 27;. doi: 10.1109/TMI.2019.2902073. [Epub ahead of print] PubMed PMID: 30835220; PubMed Central PMCID: PMC9016495.

Lee MH, O'Hara NB, Nakai Y, Luat AF, Juhasz C, Sood S, Asano E, Jeong JW. Prediction of postoperative deficits using an improved diffusion-weighted imaging maximum a posteriori probability analysis in pediatric epilepsy surgery. J Neurosurg Pediatr. 2019 Feb 22;:1-12. doi: 10.3171/2018.11.PEDS18601. [Epub ahead of print] PubMed PMID: 30797207; PubMed Central PMCID: PMC9019725.

Nakai Y, Sugiura A, Brown EC, Sonoda M, Jeong JW, Rothermel R, Luat AF, Sood S, Asano E. Four-dimensional functional cortical maps of visual and auditory language: Intracranial recording. Epilepsia. 2019 Feb;60(2):255-267. doi: 10.1111/epi.14648. Epub 2019 Feb 1. PubMed PMID: 30710356; PubMed Central PMCID: PMC6365188.

Motoi H, Miyakoshi M, Abel TJ, Jeong JW, Nakai Y, Sugiura A, Luat AF, Agarwal R, Sood S, Asano E. Phase-amplitude coupling between interictal high-frequency activity and slow waves in epilepsy surgery. Epilepsia. 2018 Oct;59(10):1954-1965. doi: 10.1111/epi.14544. Epub 2018 Aug 26. PubMed PMID: 30146766; PubMed Central PMCID: PMC6204289.

Kim JA, Jeong JW, Behen ME, Pilli VK, Luat A, Chugani HT, Juhász C. Metabolic correlates of cognitive function in children with unilateral Sturge-Weber syndrome: Evidence for regional functional reorganization and crowding. Hum Brain Mapp. 2018 Apr;39(4):1596-1606. doi: 10.1002/hbm.23937. Epub 2017 Dec 23. PubMed PMID: 29274110; PubMed Central PMCID: PMC5847469.

John F, Maqbool M, Jeong JW, Agarwal R, Behen ME, Juhász C. Deep cerebral vein expansion with metabolic and neurocognitive recovery in Sturge-Weber syndrome. Ann Clin Transl Neurol. 2018 Apr;5(4):502-506. doi: 10.1002/acn3.546. eCollection 2018 Apr. PubMed PMID: 29687028; PubMed Central PMCID: PMC5899918

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