Jeong-Won Jeong, PhD

Jeong-Won Jeong, PhD

ef5416@wayne.edu; jeongwon@pet.wayne.edu

(313) 993-0258

(313) 993-9229 (fax)

Jeong-Won Jeong, PhD

Office Address

 GF 158F, Translational Imaging Laboratory, PET center

Children's Hospital of Michigan

3901 Beaubien St. Detroit, MI 48201

Narrative Bio

Jeong-Won Jeong, Ph.D., is an Associate Professor of Pediatrics and Neurology, MRI physicist and neuroimaging researcher in Positron Emission Tomography (PET) Center located at Children's Hospital of Michigan, Detroit. Dr. Jeong received a B.S in Biomedical Engineering from Yonsei University, Korea, a M.S. in Electrical Engineering from the University of Southern California,  and a doctorate in Biomedical Engineering from the University of Southern California. He completed a postdoctoral fellowship at University of Southern California in the Department of Radiology and Alfred E. Mann Institute for Biomedical Engineering. His research and clinical interest include functional and structural imaging biomarkers for the diagnosis of Epilpesy, Developmental Delay, Autisms, Sturge Weber Syndrome, and Borderline Personality Disorder. He has more than 50 peer-reviewed publications, is the principal investigator of an R01 grant project funded by the National Institutes of Health to study an advanced diffusion MRI tractography methodology minimizing postoperative deficits in pediatric epilpesy surgery, a Co-Investigator on four additonal R01s to develop advanced multimodal imaging methodologies including MRI, PET and electrocorticography in order to accurately detect early onset of pediatric neurological disorders. 

Academic Rank

 Associate Professor with Tenure

Undergraduate

Yonsei University, Korea, B.S., 1991

Graduate

University of Southern California, M.S., Biomedical Engineering, 2000

University of Southern California, M.S., Electrical Engineering, 2002

University of Southern California, Ph.D., Biomedical Engineering, 2002

Position Title

Associate Professor of Pediatrics, Neurology and Translational Neuroscience Program

Fellowships

Alfred E. Mann Institute for Biomedical Engineering, 2002-2007

University of Southern California, Radiology, 2004-2009

Specialties

Peidatric multimodal neuroimaging including MRI, PET and ECoG

Interests

Development of functional and structural neuroimaging techniques using diffusion tractography, functional MRI, PET and ECoG in children with epilpepsy, developmental delay, autisms, sturge-weber syndrome, and borderline personality disorder. 

Advanced brain network analyses using deep learning techniques to quantify and detect brain abnormalites in children.
 
Presurgical planning computer algorithms to determine whether the seizure focus affects functionally important neural pathways in children with focal epilepsy.
 
Imaging and genotyping of children with developmental delay to investigate the relation of genotype with MRI phenotype and behavioral deficits in children with developmental delay and impairment.
 

Publications

Media  article and interview

 "PET/MRI Leads to Potential Biomarkers for Autisms Spectrum Disorders ", Radiological Society of North America (RSNA) news, vol. 22, no. 8, pp. 7-8.

 "PET, MR Show Promise in Evaluating Children with Developmental Disabilities", RSNA Daily Bulletin, Nov 30, 2011, p. 14A.

 "Diffusion Tensor MRI technique for Autism Spectrum Disorders" , RSNA On-the-Air station, Nov. 30, 2010.

  Peer-Reviewed Publications

Pilli VK, Jeong JW, Konka P, Kumar A, Chugani HT, Juhasz C. Objective PET study of glucose metabolism asymmetries in children with epilepsy: Implications for normal brain development. Hum Brain Mapp. 2018 Aug 23. doi: 10.1002/hbm.24354. [Epub ahead of print].

Motoi H, Miyakoshi M, Abel TJ, Jeong JW, Nakai Y, Sugiura A, Luat AF, Agarwal R, Sood S, Asano E. Phaseamplitude coupling between interictal highfrequency activity and slow waves in epilepsy surgery. Epilepsia. 2018 Aug 26. doi: 10.1111/epi.14544. [Epub ahead of print]

John F, Maqbool M, Jeong JW, Agarwal R, Behen ME, Juhasz C, Deep cerebral vein expansion with metabolic and neurocognitive recovery in Sturge-Weber syndrome, Ann Clin Transl Neurol. 2018 Mar 12;5(4):502-506. doi: 10.1002/acn3.546. eCollection 2018 Apr.

Nakai Y, Magashima A, Hayakawa A, Osuki T, Jeong JW, Sugiura A, Brown EC, Asano E, Four-dimensional map of the human early visual system, Clin Neurophysiol. 2018 Jan;129(1):188-197. doi: 10.1016/j.clinph.2017.10.019. Epub 2017 Dec 1.

Kim JA, Jeong JW, Behen ME, Pilli VK, Luat A, Chugani HT, Juhász C, Metabolic correlates of cognitive function in children with unilateral Sturge-Weber syndrome: evidence for regional functional reorganization and crowing, Hum Bran Mapp. 2018; 39(4):1596-1606

Kambara T, Brown E, Jeong JW, Ofen N, Nakai Y, Asano E. Spatio-temporal dynamics of working memory maintenance and scanning of verbal information. Clin Neuorphysiol. 2017; 128:882-891.

Jeong JW, Asano E, Juhász C, Behen ME, Chugani HT. Objective 3D surface evaluation of intracranial electrophysiologic correlates of cerebral glucose metabolic abnormalities in children with focal epilepsy. Hum Brain Mapp. 2017; doi: 10.1002/hbm.23577. [Epub ahead of print].

Nakai Y, Jeong JW, Brown E, Rothermel R, Kojima K, Kambara K, Shah A, Mittal S, Sood S, Asano E. Three- and four-dimensional mapping of speech and language inpatients with epilepsy. Brain. 2017; doi: 10.1093/brain/awx051. [Epub ahead of print].

Jeong JW, Asano E, Juhász C, Behen ME, Chugani HT. Postoperative axonal changes in the contralateral hemisphere in children with medically refractory epilepsy: A longitudinal diffusion tensor imaging connectome analysis. Hum Brain Mapp. 2016; 37:3946-56.

Jeong JW, Sundaram S, Behen ME, Chugani HT. Relationship between genotype and arcuate fasciculus morphology in six young children with global developmental delay: Preliminary DTI study. J Magn Reson Imaging. 2016; 44(6): 1054-12.

Kamson DO, Pilli VK, Asano E, Jeong JW, Sood S, Juhász C, Chugani HT. Cortical thickness asymmetries and surgical outcome in neocortical epilepsy. J Neurol Sci. 2016; 368: 97-103.

Jeong JW, Sundaram S, Behen ME, Chugani HT. Differentiation of speech delay and global developmental delay in children using DTI tractography-based connectome. Am J. Neuroradiol. 2016; 37:1170-7.

Jeong, JW, Juhász C, Mittal S, Bosnyak E*, Kamson DO, Barger GR, Robinette NL, Kupsky WJ, Chugani DC. Multi-modal imaging of tumor cellularity and Tryptophan metabolism in human Gliomas. Cancer Imaging. 2015; 15(1):10

Kamson DO, Juhász C, Chugani HT, Jeong JW. Novel diffusion tensor imaging technique reveals developmental streamline volume changes in the corticospinal tract associated with leg motor control. Brain Dev. 2015; 37(4): 370-5.

Jeong JW, Asano E, Juhász C, Chugani HT. Localization of specific language pathways using diffusion-weighted imaging tractography for presurgical planning of children with intractable epilepsy. Epilepsia. 2015 Jan;56:49-57.

Jeong, JW, Lee J, Kamson DO, Chugani HT, Juhász C. Detection of hand and leg motor tract injury using novel diffusion tensor MRI tractography in children with central motor dysfunction, Magn Reson Imaging. 2015; 33(7):895-902.

Jeong JW, Tiwari VN, Shin J, Chugani HT, Juhász C. Assessment of brain damage and plasticity in the visual system due to early occipital lesion: comparison of FDG-PET with diffusion MRI tractography. J Magn Reson Imaging. 2015; 41(2): 431-38.

Jeong JW, Tiwari VN, Behen ME, Chugani HT, Chugani DC. In vivo detection of reduced Purkinje cell fibers with diffusion MRI tractography in children with autistic brain disorders. Front. Hum. Neurosci. 2014 Feb 28; 8:100. doi:10.3389/fnhum.2014.00110.

Jeong JW, Asano E, Juhász C, Chugani HT. Quantification of primary motor pathways using diffusion MRI tractography and its application to predict postoperative motor deficits in children with focal epilepsy. Hum Brain Mapp. 2014; 35(7):3216-26.

Kamson DO, Juhász C, Shin J, Behen ME, Guy WC, Chugani HT, Jeong JW. Pattern of structural reorganization of the corticospinal tract in children with Sturge-Weber syndrome. Pediatr Neurol. 2014; 50(4): 337-42.

Brown EC, Jeong JW, Muzik O, Rothermel R, Matsuzaki N, Juhasz C, Sood S, Asano E. Evaluating the arcuate fasciculus with combined diffusion weighted MRI tractography and electrocorticography. Hum Brain Mapp. 2014 May; 35(5):2333-47.

Jeong JW, Chugani HT, Juhász C. Localization of function-specific segments of the primary motor pathway in children with Sturge-Weber syndrome: a multimodal imaging analysis. J Magn Reson Imaging. 2013; 38(5):1152-61.

Jeong JW, Chugani HT, Behen ME, Guy W, Juhász C. Quantitative assessment of brain networks in children with Sturge-Weber syndrome using resting state functional magnetic resonance imaging (MRI).  J Child Neurol. 2013; 28(11):1448-1455.

Jeong JW, Asano E, Yeh FC, Chugani DC, Chugani HT. Independent component analysis tractography combined with a ball-stick model to isolate intra-voxel crossing fibers of the corticospinal tracts in children with diffusion MRI. Magn Reson Med. 2013; 70(2):441-453.

Jeong JW, Asano E, Brown EC, Tiwari VN, Chugani DC, Chugani HT. Automatic detection of primary motor areas using diffusion MRI tractography: comparison with functional MRI and electrical stimulation mapping. Epilepsia. 2013 54(8):1381-90.

Gorvindan RM, Asano E, Juhász C, Jeong JW, Chugani HT. Surface based laminar analysis of cortical and white matter layers and identification of diffusion changes in the epileptic cortex.  Epilepsia, 2013; 54(4):667-77.

Thomason ME, Dassanayake MT, Shen S, Katkuri Y, Alexis M, Anderson AL, Yeo L, Mody S, Andrade EH, Hassan SS, Studholme C, Jeong JW, Romero R. Cross-hemispheric functional connectivity in the human fetal brain. Sci Transl Med, 2013; 5(173).

Jeong JW, Chugani DC, Behen ME, Tiwari VN*, Chugani HT. Altered white matter structure of the dentatorubrothalamic pathway in children with autistic spectrum disorders. Cerebellum. 2012; 11(4):957-71.

Tiwari VN, Jeong JW, Wilson BJ, Behen ME, Chugani HT, Sundaram SK. Relationship between aberrant brain connectivity and clinical features in Angelman Syndrome: a new method using tract based spatial statistics of DTI color-coded orientation maps. Neuroimage. 2012; 59(1):349-55.

Tiwari VN, Jeong JW, Asano E, Rothermel R, Juhász C, Chugani HT. A sensitive diffusion tensor imaging quantification method to detect language tract laterality in children with the Wada test.  J Child neurol. 2011; 26(12):1516-21.

Jeong JW, Kumar A, Sundram SK, Chugani DC, Chugani HT. Sharp curvature of frontal lobe white matter pathways in children with autism spectrum disorder: tract-based morphometry analysis. Am J. Neuroradiol. 2011; 32(9):1600-6.

Alkonyi B, Juhász C, Muzik O, Behen ME, Jeong JW, Chugani HT. Thalamocortical connectivity in healthy children: Asymmetries and robust developmental changes between age 8 to 17. Am J. Neuroradiol. 2011;  32(5):962-9.

Wilson BJ, Sundaram SK, Huq AHM, Jeong JW, Halverson SR, Behen ME, Bui DQ, Chugani HT. Abnormal Language Pathway in Children with Angelman Syndrome.  Pediatric Neurology. 2011; 44(5):350-6.

Jeong JW, Diwadkar V, Chugani CD, Sinsoongsud P, Mizik O, Behen ME, Chugani HT, Chugani DC. Congruence of happy and sad emotion in music and faces modifies cortical audiovisual activation. Neuroimage, 2011; 54(4):2973-82.

Jeong JW, Sundram SK, Kumar A, Chugani DC, Chugani HT. Aberrant diffusion and geometric properties in left arcuate fasciculus of developmentally delayed children: A diffusion tensor MRI study. Am J. Neuroradiol. 2011; 32(2):323-30.

Alkonyi B, Govindan RM, Chugani HT, Behen ME, Jeong JW, Juhász C. Focal white matter abnormalities related to neurocognitive dysfunction: an objective diffusion tensor imaging study of children with Sturge-Weber syndrome. Pediat Res. 2011; 69(1):74-9.

Singh M, Jeong JW, Hwang D. Novel DTI methodology to detect and quantify injured regions and affected brain pathways in traumatic brain injury. Magn Reson Imaging. 2010 28(1):22-40.

Jeong JW, Shin D, Marmarelis VZ. Image fusion methodology for efficient interpretation of multi-band images in 3-D high resolution ultrasonic transmission tomography. International Journal of Imaging Systems and Technology. 2009; 19(4): 277-82.

Jeong JW, Shin D, Do SH, Blanco C, Klipfel NE, Homes DR, Hovanessian-Larsen LJ, Marmarelis VZ. Differentiation of cancerous lesions in excised human breast specimens using multi-band attenuation profiles from ultrasonic transmission tomography. Journal of ultrasound in medicine. 2008 Mar; 27(3):435-51.

Marmarelis VZ, Jeong JW, Shin DC, Do S. High-resolution 3-D imaging and tissue differentiation with transmission tomography. Acoustic imaging, 2007, 195-206.

Jeong JW, Shin D, Do SH, Marmarelis VZ, Segmentation methodology for automated classification and differentiation of soft tissues in multi-band images of high-resolution ultrasonic transmission tomography. IEEE Trans. on Medical Imaging. 2006; 25(8): 1068-78.

Jeong JW, Kim TS, Shin D, Do DH, Singh M, Marmarelis VZ, Soft tissue differentiation using multi-band signatures of high resolution ultrasonic transmission tomography. IEEE Trans. on Medical Imaging. 2005; 24(3): 399-408.

Kim S, Jeong JW, Singh M. Estimation of multiple fiber tract orientations from diffusion tensor MRI using independent component analysis. IEEE Trans. on Nuclear Science. 2005; 52(1): 266-73.

Jeong JW, Kim TS, Kim S, Singh M. Application of independent component analysis with mixture density model to localize the brain alpha activity in fMRI and EEG. International Journal of Imaging Systems and Technology. 2004; 14(4): 170-80.

Singh M, Sungkarat W, Jeong JW, Zhou Y. Extraction of temporal information in functional MRI. IEEE Trans. on Nuclear Science, 2002; 49(5): 2284-90.

Singh M, Jeong JW, Al-Dayeh L, Kim TS, Colletti P. Cross-correlation technique to identify activated pixels in a three-condition fMRI task. IEEE Trans. on Nuclear Science, 1999; 46(3): 520-26.  

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