Eishi Asano, MD, PhD

Eishi Asano, MD, PhD

easano@med.wayne.edu

313 745 5788

313 745 5074 clinic (fax)

Eishi Asano, MD, PhD

Narrative Bio

Dr. Eishi Asano, Professor of Pediatrics and Neurology, is a leading expert on functional brain mapping. He has served as Teaching Faculty in Wayne State University and Medical Director of Neurodiagnostics in Children’s Hospital of Michigan since 2004. He has played a central role in epilepsy presurgical evaluation, including invasive monitoring, for >500 patients ranging from neonates to adults. As the first or last author, he published 51 papers related to intracranial neural recording and/or stimulating technologies in main-stream neurology and neuroscience journals from 2008 to 2017 alone; six were accompanied by an editorial and five were featured as the journal cover. His research activity has been supported by NIH grants since 2004. His recent academic achievement includes establishment of four-dimensional functional brain atlas, which animates the dynamics of neural modulations elicited by sensory, motor, or cognitive tasks on 3D standardized or individual brain surface images with a temporal resolution of 1.0 – 10.0 ms (Brain 2017;140:1351-1370). He served as an editorial board member of Clinical Neurophysiology, the Official Journal of the International Federation of Clinical Neurophysiology from 2009 to 2016. He was selected as 2017 Health Care Hero by Crain's Detroit Business.

Research Summary:
Dr. Asano’s ultimate research goal is to optimize the seizure outcome and the quality of life of patients who undergo epilepsy surgery. We have recently established a unique mapping method referred to as ‘4D brain map’ (Brain 2017;140:1351-1370). It accurately animates when and where brain regions are activated and suppressed on a 3D surface image with an excellent spatial-temporal resolution (≤0.01 second / ≤1 cm). Please let Dr. Asano know if you are interested in our research program.

Office Address

Children's Hospital of Michigan, Pediatrics, Detroit, MI, 48201

Awards & Honors

2003: Young Investigator Award at the 57th Annual Meeting of the American Epilepsy Society.
2004: Wolf W. Zuelzer Fellow Research Award. Children's Hospital of Michigan.
2004: Travel Fellowship Award at the 58th Annual Meeting of the American Clinical Neurophysiology Society.
2004: NIH Mentored Patient-Oriented Research Career Development Award (K23 Award).
2006: Juhn and Mary Wada Prize. Japan Epilepsy Society.
2008: School of Medicine College Teaching Award. Wayne State University.
2009-2016: Editorial Board Member in Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology.
2009-present: Editorial Board Member in Brain and Development: Official Journal of the Japanese Society of Child Neurology.
2016: Fellow of the American Epilepsy Society.
2017: Health Care Hero. Crain’s Detroit Business.

Other Information

Grant funding from National Institute of Neurological Disorders and Stroke (NINDS). Title: Functional Brain Mapping in Pediatric Neurosurgery. Period: 2009-2019.

Graduate

Tohoku University, Japan, Ph.D., 2002; Neurosurgery University of Michigan, Ann Arbor, M.S., 2007 Clinical Research Design and Statistical Analysis

Medical

Tohoku University School of Medicine, Sendai, Japan. MD conferred in 1996.

Position Title

Professor of Pediatrics and Neurology

Residency

Tohoku University School of Medicine, Sendai, Japan. 1996-1998.

Specialties

pediatric-program

Fellowships

Children’s Hospital of Michigan, Pediatric Neuroimaging Research, 1998-2002;
Children’s Hospital of Michigan, Pediatric Neurophysiology Research, 2000-2002;
Children’s Hospital of Michigan, Pediatric Neurology/Clinical Neurophysiology, 2002-2004 

Interests

Epilepsy, Clinical Neurophysiology, and Human Brain Mapping

Publications

 (SELECTED: *: student or trainee):
1. Kambara T*, Sood S, Alqatan Z*, Klingert C*, Ratnam D*, Hayakawa A*, Nakai Y*, Luat AF, Agarwal R*, Rothermel R, Asano E. Presurgical language mapping using event-related high-gamma activity: the Detroit procedure. Clin Neurophysiol 2018;129:145-154.
2. Nakai Y*, Nagashima A*, Hayakawa A*, Osuki T*, Jeong JW, Sugiura A*, Brown EC*, Asano E. Four-dimensional map of the human early visual system. Clin Neurophysiol 2018;129:188-197. (featured as the cover figure)
3. Nishida M*, Korzeniewska A, Crone NE, Toyoda G*, Ofen N, Brown EC*, Asano E. Brain network dynamics in the human articulatory loop. Clin Neurophysiol 2017;128:1473-1487. (selected as the highlight and featured as the cover figure)
4. Kambara T*, Brown EC*, Jeong JW, Ofen N, Nakai Y*, Asano E. Spatio-temporal dynamics of working memory maintenance and scanning of verbal information. Clin Neurophysiol 2017;128:882-891.
5. Nakai Y*, Jeong JW, Brown EC*, Rothermel R, Kojima K*, Kambara T*, Shah A, Mittal S, Sood S, Asano E. Three- and four-dimensional mapping of speech and language in patients with epilepsy. Brain 2017;140:1351-1370.
6. Asano E. Invited editorial: High-frequency oscillations are under your control. Don’t chase all of them. Clin Neurophysiol 2017;128:841-842.
7. Nonoda Y*, Miyakoshi M, Ojeda A, Makeig S, Juhasz C, Sood S, Asano E. Interictal high-frequency oscillations generated by seizure onset and eloquent areas may be differentially coupled with different slow waves. Clin Neurophysiol 2016;127:2489-99.
8. Nishida M*, Zestos MM, Asano E. Spatial-temporal patterns of electrocorticographic spectral changes during midazolam sedation. Clin Neurophysiol 2016;127:1223-32.
9. Asano E, Gotman J. Invited editorial: Is electrocorticography-based language mapping ready to replace stimulation? Neurology 2016;86:1174-6.
10. Chugani HT, Ilyas M, Kumar A, Juhász C, Kupsky WJ, Sood S, Asano E. Surgical treatment for refractory infantile spasms: the Detroit series. Epilepsia 2015;56:1941-9.
11. Matsuzaki N*, Schwarzlose R, Nishida M*, Ofen N, Asano E. Upright face-preferential high-gamma responses in lower-order visual areas: evidence from intracranial recordings in children. Neuroimage 2015;109:249–59.
12. Ueda K*, Brown EC*, Kojima K*, Juhász C, Asano E. Mapping mental calculation systems with electrocorticography. Clin Neurophysiol 2015;126:39-46.
13. Cho-Hisamoto Y*, Kojima K*, Brown EC*, Matsuzaki N*, Asano E. Gamma activity modulated by naming of ambiguous and unambiguous images: intracranial recording in epileptic patients. Clin Neurophysiol 2015;126:17-26. (featured as the cover figure)
14. Chugani HT, Asano E, Juhász C, Kumar A, Kupsky WJ, Sood S. ‘Subtotal’ hemispherectomy in children with intractable focal epilepsy. Epilepsia 2014;55:1926-33 (featured as the cover figure)
15. Brown EC*, Muzik O, Rothermel R, Juhász C, Shah AK, Fuerst D, Mittal S, Sood S, Asano E. Evaluating signal-correlated noise as a control task with language-related gamma activity on electrocorticography. Clin Neurophysiol 2014;125:1312-1323.
16. Toyoda G*, Brown EC*, Matsuzaki N*, Kojima K*, Nishida M*, Asano E. Electrocorticographic correlates of overt articulation of 44 English phonemes: intracranial recording in children with focal epilepsy. Clin Neurophysiol 2014;125:1129-1137. (featured as the cover figure)
17. Brown EC*, Jeong JW, Muzik O, Rothermel R, Matsuzaki N*, Juhász C, Sood S, Asano E. Evaluating the arcuate fasciculus with combined diffusion MRI and electrocorticography. Hum Brain Mapp 2014;35:2333-2347.
18. Asano E. Invited letter to the editor. Contribution of research on 'Epilepsy & Behavior' to the refinement of functional brain atlas in four dimensions. Epilepsy Behav 2014;40:86-88.
19. Miyakoshi M*, Delorme A, Mullen T, Kojima K, Makeig S, Asano E. Automated detection of cross-frequency coupling in the electrocorticogram for clinical inspection. Conf Proc IEEE Eng Med Biol Soc2013;2013:3282-3285.
20. Kojima K*, Brown EC*, Matsuzaki N*, Asano E. Animal category-preferential gamma-band responses in the lower- and higher-order visual areas. Clin Neurophysiol 2013;124:2368-2377. (published with an accompanying editorial)
21. Uematsu M*, Matsuzaki N*, Brown EC*, Kojima K*, Asano E. Human occipital cortices differentially exert saccadic suppression. Neuroimage 2013;83:224-236.
22. Chugani HT, Luat AF*, Kumar A, Govindan R, Pawlik K, Asano E. Alpha-[11C]-methyl-L-tryptophan PET in 191 patients with tuberous sclerosis complex. Neurology 2013;81:674-680.
23. Matsuzaki N*, Juhász C, Asano E. Cortico-cortical evoked potentials and stimulation-elicited gamma activity preferentially propagate from lower- to higher-order visual areas. Clin Neurophysiol 2013;124:1290-1296.
24. Kojima K*, Brown EC*, Matsuzaki N*, Rothermel R, Fuerst D, Shah A, Mittal S, Sood S, Asano E. Gamma activity modulated by picture and auditory naming tasks: intracranial recording in patients with focal epilepsy. Clin Neurophysiol 2013;124:1737-1744. (published with an accompanying editorial)
25. Kojima K*, Brown EC*, Rothermel R, Carlson A*, Fuerst D, Matsuzaki N*, Shah A, Atkinson M, Basha M, Mittal S, Sood S, Asano E. Clinical significance and developmental changes of auditory-language-related gamma activity. Clin Neurophysiol 2013;124:857-869. (published with an accompanying editorial)
26. Asano E, Brown EC*, Juhász C. How to establish causality in epilepsy surgery. Brain Dev 2013;35:706-720.
27. Asano E, Goadsby PJ. Invited editorial: How do we fashion better trials for neurostimulator studies in migraine? Neurology 2013;80:694.
28. Brown EC*, Matsuzaki N*, Asano E. The transient effect of interictal spikes from a frontal focus on language-related gamma activity. Epilepsy Behav 2012;24:497-502.
29. Kumar G*, Juhasz C, Sood S, Asano E. Olfactory hallucinations elicited by electrical stimulation via subdural electrodes: Effects of direct stimulation of olfactory bulb and tract. Epilepsy Behav 2012;24:264-268.
30. Kojima K*, Brown EC*, Rothermel R, Carlson A*, Matsuzaki N*, Shah A, Atkinson M, Mittal S, Fuerst D, Sood S, Asano E. Multimodality language mapping in patients with left-hemispheric language dominance on Wada test. Clin Neurophysiol 2012;123:1917-1924. (published with an accompanying editorial)
31. Matsuzaki N*, Juhász C, Asano E. Oscillatory modulations in human fusiform cortex during motion-induced blindness: intracranial recording. Clin Neurophysiol 2012;123:1925-1930.
32. Brown EC*, Muzik O, Rothermel R, Matsuzaki N*, Juhász C, Shah AK, Atkinson MD, Fuerst D, Mittal S, Sood S, Diwadkar VA, Asano E. Evaluating reverse speech as a control task with language-related gamma-oscillations on electrocorticography. Neuroimage 2012;60:2335-2345.
33. Cho-Hisamoto Y*, Kojima K*, Brown EC*, Matsuzaki N*, Asano E. Cooing- and babbling-related gamma-oscillations during infancy: intracranial recording. Epilepsy Behav 2012;23:494-496. (featured as the cover figure)
34. Nagasawa T*, Juhász C, Rothermel R, Hoechstetter K, Sood S, Asano E. Spontaneous and visually-driven high-frequency oscillations in the occipital cortex: Intracranial recording in epileptic patients. Hum Brain Mapp 2012;33:569-583.
35. Matsuzaki N*, Nagasawa T*, Juhasz C, Sood S, Asano E. Independent predictors of neuronal adaptation in human primary visual cortex measured with high-gamma activity. Neuroimage 2012;59:1639-1646.
36. Nariai H*, Matsuzaki N*, Juhász C, Nagasawa T*, Sood S, Chugani HT, Asano E. Ictal high-frequency oscillations coupled with delta phase in epileptic spasms. Epilepsia 2011;52:e130-e134.
37. Koga S*, Rothermel R, Juhász C, Nagasawa T*, Sood S, Asano E. Electrocorticographic correlates of cognitive control in a Stroop task. -Intracranial recording in epileptic patients- Hum Brain Mapp 2011;32:1580-1591.
38. Nagasawa T*, Matsuzaki N*, Juhász C, Hanazawa A, Shah A, Mittal S, Sood S, Asano E. Occipital gamma-oscillations modulated during eye movement tasks: simultaneous eye tracking and electrocorticography recording. Neuroimage 2011;58:1101-1109.
39. Wu H*, Nagasawa T*, Brown EC*, Juhász C, Rothermel R, Hoechstetter K, Shah A, Mittal S, Fuerst D, Sood S, Asano E. Gamma-oscillations modulated by picture naming and word reading: Intracranial recording in epileptic patients. Clin Neurophysiol 2011;122:1929-2942. (featured as the cover figure)
40. Nariai H*, Nagasawa T*, Juhasz C, Sood S, Chugani HT, Asano E. Statistical mapping of ictal high-frequency oscillations in epileptic spasms. Epilepsia 2011;52:63-74.
41. Thampratankul L*, Nagasawa T*, Rothermel R, Juhasz C, Sood S, Asano E. Cortical Gamma-Oscillations Modulated by Word Association Tasks. - Intracranial Recording - Epilepsy Behav 2010;18:116-118.
42. Nagasawa T*, Rothermel R, Juhász C, Nishida M*, Sood S, Asano E. Cortical gamma-oscillations modulated by visuomotor tasks -Intracranial recording in patients with epilepsy- Epilepsy Behav 2010;18:254-261.
43. Nagasawa T*, Rothermel R, Juhász C, Fukuda M*, Nishida M*, Akiyama T, Sood S, Asano E. Cortical gamma-oscillations modulated by auditory-motor tasks. -Intracranial recording in patients with epilepsy- Hum Brain Mapp 2010;31:1627-1642.
44. Fukuda M*, Juhász C, Hoechstetter K, Sood S, Asano E. Somatosensory-related gamma-, beta- and alpha-augmentation precedes alpha-beta attenuation in humans. Clin Neurophysiol 2010;121:366-375. (published with an accompanying editorial)
45. Fukuda M*, Rothermel R, Juhász C, Nishida M*, Sood S, Asano E. Cortical gamma-oscillations modulated by listening and overt repetition of phonemes. Neuroimage 2010;49:2735-2745.
46. Nishida M*, Sood S, Asano E. In-vivo animation of midazolam-induced electrocorticographic changes in humans. J Neurol Sci 2009;287:151-158.
47. Asano E, Juhász C, Shah A, Sood S, Chugani HT. Role of subdural electrocorticography in prediction of long-term seizure outcome in epilepsy surgery. Brain 2009;132:1038-1047.
48. Asano E, Nishida M*, Fukuda M*, Rothermel R, Juhász C, Sood S. Differential visually-induced gamma-oscillations in human cerebral cortex. Neuroimage 2009;45:477-489.
49. Nishida M*, Juhász C, Sood S, Chugani HT, Asano E. Cortical Glucose Metabolism Positively Correlates with Gamma-Oscillations in Nonlesional Focal Epilepsy. Neuroimage 2008;42:1275-1284.
50. Fukuda M*, Nishida M*, Juhász C, Muzik O, Sood S, Chugani HT, Asano E. Short-Latency Median-Nerve Somatosensory-Evoked Potentials and Induced Gamma-Oscillations in Humans. Brain 2008;131:1793-1805.
51. Brown EC*, Rothermel R, Nishida M*, Juhász C, Muzik O, Sood S, Chugani HT, Asano E. In-Vivo Animation of Auditory-Language-Induced Gamma-Oscillations in Children with Intractable Focal Epilepsy. Neuroimage 2008;41:1120-1131.
52. Nishida M*, Asano E, Juhász C, Muzik O, Sood S, Chugani HT. Cortical glucose metabolism correlates negatively with delta-slowing and spike-frequency in epilepsy associated with tuberous sclerosis. Hum Brain Mapp 2008;29:1255-1264.
53. Haseeb A*, Asano E, Juhasz C, Shah A, Sood S, Chugani HT. Young patients with focal seizures may have the primary motor area for the hand in the postcentral gyrus. Epilepsy Res 2007;76:131-139.
54. Asano E, Mihaylova T*, Juhász C, Sood S, Chugani HT. Effect of sleep on interictal spikes and distribution of sleep spindles on electrocorticography in children with focal epilepsy. Clin Neurophysiol 2007;118:1360-1368.
55. Asano E. A public outreach in epilepsy surgery using a serial novel on BLOG. –a preliminary report- Brain Dev 2007;29:102-104.
56. Asano E, Pawlak C, Shah A, Shah J, Luat AF*, Ahn-Ewing J, Chugani HT. The Diagnostic Value of Initial Long-term Video-EEG Monitoring in Children. –Review of 1000 Cases- Epilepsy Res 2005;66:129-135.
57. Asano E, Juhász C, Shah A, Muzik O, Chugani DC, Shah J, Sood S, Chugani HT. Origin and Propagation of Epileptic Spasms Delineated on Electrocorticography. Epilepsia 2005;46:1086-1097.
58. Asano E, Muzik O, Shah A, Juhász C, Chugani DC, Kagawa K, Benedek K, Sood S, Gotman J, Chugani HT. Quantitative Visualization of Ictal Subdural EEG Changes in Children with Neocortical Focal Seizures. Clin Neurophysiol 2004;115:2718-2727.
59. Asano E, Benedek K, Shah A, Juhász C, Shah J, Chugani DC, Muzik O, Sood S, Chugani HT. Is intraoperative electrocorticography reliable in children with intractable neocortical epilepsy? Epilepsia 2004;45:1091-1099.
60. Asano E, Muzik O, Shah A, Juhász C, Chugani DC, Sood S, Janisse J, Ergun EL, Ahn-Ewing J, Shen C, Gotman J, Chugani HT. Quantitative Interictal Subdural EEG Analyses in Children with Neocortical Epilepsy. Epilepsia 2003;44:425-434.
61. Asano E, Diane C. Chugani, Csaba Juhász, Otto Muzik, Harry T. Chugani. Surgical Treatment of West Syndrome. Brain Dev 2001;23:668-676.
62. Asano E, Chugani DC, Muzik O, Behen M, Janisse J, Rothermel R, Mangner TJ, Chakraborty PK, Chugani HT. Autism in Tuberous Sclerosis Complex is Related to Both Cortical and Subcortical Dysfunction. Neurology 2001;57:1269-1277. (published as a highlight and selected for news release from the American Academy of Neurology)
63. Asano E, Chugani DC, Muzik O, Shen C, Juhász C, Janisse J, Ager J, Canady A, Shah JR, Shah AK, Watson C, Chugani HT. Multimodality Imaging for Improved Detection of Epileptogenic Foci in Tuberous Sclerosis Complex. Neurology 2000;54:1976-1984.

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