Csaba Juhasz

Csaba Juhasz

csaba.juhasz@wayne.edu

313-966-5136

313-966-9228 (fax)

Csaba Juhasz

Narrative Bio

Csaba Juhász, M.D., Ph.D. is a Professor of Pediatrics, Neurology, and Neurosurgery at Wayne State University School of Medicine. He is also a scientific member of the Karmanos Cancer Institute. He previously was a faculty member of the Department of Neurology at the Semmelweis University in Budapest, Hungary, between 1994 and 2000, where he was involved in clinical work and research in epilepsy, clinical electrophysiology, stroke, and neurology intensive care. He completed a visiting research fellowship at the Department of Neurophysiology at the University of California, Los Angeles, in 1994-95. After completing a postdoctoral fellowship at the Positron Emission Tomography (PET) Center, Children's Hospital of Michigan (CHM) in Detroit, he became an assistant professor of Pediatrics and Neurology at WSU in 2001. He received his PhD from epilepsy imaging in 2002. He was promoted to associate professor with tenure in 2008 and to full professor in 2013 at Wayne State University.

Dr. Juhász's research interests are in functional and structural neuroimaging of epilepsy, brain tumors, and developmental brain disorders, with a particular interest in the pathophysiology and progression of Sturge-Weber syndrome. He performed extensive research applying multimodal neuroimaging, combining magnetic resonance imaging techniques with PET imaging using various radiotracers to measure brain glucose metabolism, benzodiazepine receptor binding and tryptophan metabolism. He has also combined these techniques with EEG to improve localization of epileptic foci in patients with medically uncontrolled epilepsy and provides multimodal imaging support to the pediatric epilepsy surgery program at CHM. Dr. Juhasz has been the principal investigator of several R01 grant projects funded by the National Institutes of Health (NIH) since 2003 to study progression of brain structural and functional abnormalities in Sturge-Weber syndrome and to explore the clinical use of tryptophan PET imaging in brain tumors.

 

Office Address

PET Center and Translational Imaging Laboratory, Children's Hospital of Michigan, Detroit, MI 48201

Awards & Honors

  • Eotvos Research Scholarship from the Hungarian Ministry of Culture and Education (1994)
  • Invited speaker at the International Conference on Human Brain Mapping (Sendai, Japan, 2002), the International Seoul Epilepsy Conference (2003) and the Annual Meeting of the Korean Epilepsy Society (2007), the Annual Meeting of the American Epilepsy Society (2004, 2010, 2013), International Epilepsy Congresses (Paris, 2005, Singapore, 2007, Budapest, 2009), national Sturge-Weber syndrome conferences (2003, 2005, 2007, 2011, 2013), the Conference on Vascular Anomalies (New York, 2007), the International Conference on the Diagnosis and Therapy in Pediatric Neurology (Poland, 2008), the Advanced Topics in Neurology course at the University of Sao Paulo (Brazil, 2008), 19th International Cleveland Clinic Epilepsy Symposium (2010), Pragua Symposium of Child Neurology and Developmental Epileptology (2011), The Annual Scientific Meeting of the International Society for neurovascular Disease (Orlando, 2012), The National Epilepsy Meeting of Hungary (Kaposvar, 2012), The Annual Meeting of the Child Neurology Society (Huntington Beach, 2013), Regional Sturge-Weber Symposium (Dearborn, 2014), ECOG-Acrin Meeting (Orlando, 2014), National Research Workshop on Sturge-Weber syndrome (Bethesda, MD, 2015), 14th International Society for Tryptophan Research Conference (Grand Rapids, MI, 2015), TRCCC Annual Meeting (Seven Springs, PA, 2016), 15th
    International Society for Tryptophan Research Conference (Hikone, Japan, 2018), The Sturge-Weber Foundation Research Network International Conference (Wilmington, DE, 2019), the Annual Meeting of the American Epilepsy Society (Baltimore, MD, 2019)
  • Wayne State University Career Development Chair Award (2009)
  • The Sturge-Weber Foundation "Champion Award", awarded at the International Sturge-Weber Conference in 2011
  • WSU SOM Teaching Award (2012)
  • WSU Research Mentors Award (2017)

Academic Rank

Professor

Other Information

Certifications: Board certification in Neurology, Hungarian Board of Neurology, 1993

Graduate

Semmelweis University, Medical School, Budapest, Hungary, Ph.D., 2002

Medical

University School Pecs, Hungary, M.D., 1989

Position Title

Professor of Pediatrics,  Neurology, Neurosurgery

Residency

University Medical School, Pecs, Hungary (Neurology), 1989-1993

Specialties

multimodal neuroimaging, epilepsy, brain mapping, ,neuro-oncology

Fellowships

Visiting research fellow, University of California, Los Angeles, Clinical Neurophysiology, 1994-1995

Postdoctoral Fellow, PET Imaging, Wayne State University, Detroit, MI 1998-2001

Prior Appointments

Assistant Professor of Neurology, Semmelweis Medical University, Budapest, Hungary, 1994-1997

Associate Professor of Neurology, Semmelweis Medical University. Budapest, Hungary, 1997-2000

Assistant Professor of pediatrics and Neurology, Wayne State University, Detroit, MI, 2001-2008

Assosiate professor of pediatrics and Neurology, Wayne State University, Detroit, 2008-2013

Interests

Functional neuroimaging, PET scanning, clinical applications of advanced multimodality imaging techniques, epilepsy pre-surgical evaluation, Sturge-Weber syndrome, brain tumor imaging

Publications

Selected from >200 peer-reviewed publications:

Juhasz C, Nagy F, Watson C, da Silva EA, Muzik O, Chugani DC, Shah J, Chugani HT. Glucose and [11C]flumazenil positron emission tomography abnormalities of thalamic nuclei in temporal lobe epilepsy. Neurology 1999;53:2037-2045.

Juhasz C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT. Is epileptogenic cortex truly hypometabolic on interictal positron emission tomography? Ann Neurol 2000;48:88-96.

Juhasz C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT. Electroclinical correlates of flumazenil and fluorodeoxyglucose PET abnormalities in lesional epilepsy. Neurology 2000;55:825-834.

Juhasz C, Chugani DC, Muzik O, Shah A, Asano E, Mangner T, Chakraborty PK, Sood S, Chugani HT. Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy. Neurology 2003;60:960-968.

 Juhasz C, Chugani DC, Muzik O, Wu D, Sloan A, Barger G, Watson C, Shah A, Sood S, Ergun EL, Mangner T, Chakraborty P, Kupsky WJ, Chugani HT. In vivo uptake and metabolism of alpha-[11C]methyl-L-tryptophanin human brain tumors. J Cereb Blood Flow Metab 2006;26:345-57.

Juhasz C. Lai C, Behen ME, Muzik O, Helder EJ, Chugani DC, Chugani HT. White matter volume as a major predictor of cognitive function in Sturge-Weber syndrome. Arch Neurol 2007;64:1169-74.

Fukuda M, Nishida M, Juhasz C, Muzik O, Sood S, Chugani HT, Asano E. Short-latency median-nerve somatosensory-evoked potentials and induced gamma oscillations in humans. Brain 2008;131:1793-805.

Asano E, Juhasz C, Shah A, Sood S, Chugani HT. Role of subdural electrocorticography in prediction of long-term seizure outcome in epilepsy surgery. Brain 2009;132;1038-47.

Kumar A, Juhasz C, Asano E, Sood S, Muzik O, Chugani HT. Objective detection of epileptic foci by FDG PET in children undergoing epilepsy surgery. J Nucl Med 2010;51:1901-7.

Juhasz C, Muzik O, Chugani DC, Chugani HT, Sood S, Chakraborty PK, Barger GR, Mittal S.Differential kinetics of alpha-[11C]methyl-L-tryptophan on PET in low-grade brain tumors. J Neurooncol 2011;102:409-415.

Alkonyi B, Chugani HT, Juhasz C. Transient focal increase of interictal glucose metabolism in Sturge-Weber syndrome: implications for epileptogenesis. Epilepsia 2011;52:1265-1272.

Juhasz C, Chugani DC, Barger GR, Kupsky WJ, Chakraborty PK, Muzik O, Mittal S. Quantitative PET imaging of tryptophan accumulation in gliomas and remote cortex: Correlation with tumor proliferative activity. Clin Nucl Med 2012;37:838-842.

Juhasz C. The impact of positron emission tomography imaging on the clinical management of patients with epilepsy. Exp Rev Neurother 2012;12:719-732.

Kamson DO, Juhasz C, Buth A, Kupsky WJ, Barger GR, Chakraborty P, Muzik O, Mittal S. Tryptophan PET in pretreatment delineation of newly-diagnosed gliomas: MRI and histopathologic correlates. J Neurooncol 2013;112:121-32.

Kamson DO, Mittal S, Robinette NL, Muzik O, Kupsky WJ, Barger GR, Juhasz C. Increased tryptophan uptake on PET has a strong independent prognostic value in patients with a previously treated high-grade glioma. Neuro Oncol 2014;16:1373-1383.

Jeong JW, Asano E, Juhasz C, Chugani HT. Quantification of primary motor pathways using diffusion MRI tractography and its application to predict postoperative motor deficits in children with focal epilepsy. Hum Brain Mapp. 2014;35:3216-3226.

Juhasz C, Dwivedi S, Kamson DO, Michelhaugh SK, Mittal S. Comparison of amino acid positron emission tomography radiotracers for molecular imaging of primary and metastatic brain tumors. Mol Imaging 2014 DOI 10.2310/7290.2014.00015

Bosnyák E, Kamson DO, Guastella A, Varadarajan K, Robinette NL, Kupsky WJ, Muzik O, Michelhaugh SK, Mittal S, Juhasz C. Molecular imaging correlates of tryptophan metabolism via the kynurenine pathway in human meningiomas.  Neuro Oncol. 2015;17:1284-92.

Juhasz C, Hu J, Xuan Y, Chugani HT. Imaging increased glutamate in children with Sturge-Weber syndrome: Association with epilepsy severity. Epilepsy Res. 2016;122:66-72.

Jeong JW, Asano E, Pilli V, Nakai Y, Chugani HT, Juhasz C. Objective 3D surface evaluation of intracranial electrophysiologic correlates of cerebral glucose metabolic abnormalities in children with focal epilepsy.Hum Brain Mapp. 2017;38:3098-3112.

Kim JA, Jeong JW, Behen ME, Pilli VK, Luat A, Chugani HT, Juhasz C. Metabolic correlates of cognitive function in children with unilateral Sturge-Weber syndrome: Evidence for regional functional reorganization and crowding. Hum Brain Mapp. 2018;39:1596-1606.

Pilli VK, Jeong JW, Konka P, Kumar A, Chugani HT, Juhasz C. Objective PET study of glucose metabolism asymmetries in children with epilepsy: Implications for normal brain development. Hum Brain Mapp 2019;40:53-64.

John F, Bosnyak E, Robinette NL, Amit-Yousif AJ, Barger GR, Shah KD, Michelhaugh SK, Klinger NV, Mittal S, Juhasz C. Multimodal imaging-defined subregions in newly-diagnosed glioblastoma: Impact on overall survival. Neuro Oncol 2019;21:264-273.

John F, Muzik O, Mittal S, Juhasz C. Fluorine-18-labeled PET radiotracers for imaging tryptophan uptake and metabolismo: A systematic review. Mol Imaging Biol 2019 Sep, doi: 10.1007/s11307-019-01430-6

Juhasz C, Shevell, M. When white matter lesions cross the (mid-ventricle) line: Predicting outcome in preterm infants. Neurology 2019;93:13:569-570.

Juhasz C. Prefrontal cortex in the driving seat of epileptic networks in Lennox-Gastaut syndrome. Neurology 2019;93:91-92.

 

 

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