Joyce Benjamins, PhD

Joyce Benjamins, PhD;

(313) 577-71275 (lab); 577-71265 (office)

(313) 577-7552 (fax)

Joyce Benjamins, PhD

Narrative Bio

Joyce A. Benjamins, Ph.D. has served in the Department of Neurology since 1995. She joined the Department of Neurology in 1975, and has maintained an active research laboratory since coming to WSU. She has served on multiple scientific review boards for NINDS and the National Multiple Sclerosis Society, and currently serves on the editorial boards of three neuroscience journals and as a section editor for the textbook Basic Neurochemistry.

Dr. Benjamins’ research interests are related to multiple sclerosis and other disorders affecting myelin. Her research projects investigate myelination, glial differentiation, glycolipid metabolism and function, and the roles of cyclic GMP and metabotropic glutamate receptors inprotecting oligodendroglia from injury. Currently she investigating the effects of glutamate receptor agonists and antagonists on disease outcome in an animal model of EAE. She collaborates with Dr. Lisak in studying the effects of cytokines on gene expression in CNS neurons and glia.

Office Address

2248 Elliman Building 421 E. Canfield Ave.

Awards & Honors

  • Phi Beta Kappa
  • Iota Sigma Pi - Agnes Faye Morgan Research Award, 1978
  • Javits Neuroscience Investigator Award, 1987-1994
  • WSU Board of Governors Distinguished Faculty Fellowship, 1988-1990
  • Nominee, Marion Spencer Fay National Award, 1998
  • Academy of Scholars, Wayne State University, 2005
  • Serves on the editorial boards of the Journal of Neuroscience Research and the International Journal of Developmental Neuroscience

Other Information


Albion College, Michigan, 1963


University of Michigan, Biochemistry, Ph.D., 1967

Position Title

Professor of Neurology, Associate of Biochemistry and Molecular Biology; Immunology/Microbiology




Stanford University School of Medicine, Pediatrics and Genetics, 1968

Prior Appointments

Assistant Professor, Neurology, Johns Hopkins School of Medicine, 1971-1973

Assistant Professor, Biochemistry, Biological Sciences Research Center, University of North Carolina School of Medicine, 1973-1975.

Assistant Professor, Neurology, Associate, Biochemistry, Wayne State University, 1975-1978

Associate Professor, Neurology & Biochemistry, Wayne State University, 1978-1985


Myelination, glial differentiation, roles of cyclic GMO and metabotropic glutamate receptors in protecting oligodendroglia from injury, glycolipid metabolism and function, effects of cytokines on gene expression in neurons and glia


Studzinski, DM and Benjamins, JA. Expression of P0 glycoprotein in CNS glia: effects of overexpression in N20.1 cells, Glia, 52: 526-532, 2005.

Benjamins, JA, Hajra, AK and Agranoff, BW.Lipids in Basic Neurochemistry, 7th edition, eds. G.J. Siegel,    R.W. Albers, S.T. Brady and D.L. Price; Elsevier Inc., San Diego CA , 2005, pp. 33-49.

Boullerne, AI and Benjamins, JA. Nitric Oxide Synthase Expression and Nitric Oxide Toxicity in Oligodendrocytes. Antioxidants and Redox Signaling, 8:967-980, 2006.

Lisak, RP, Benjamin, JA, Bealmear, B, Yao, B, Land, S, Nedelkoska, L, Skundric, D.Differential effects of Th1, monocyte/acrophage and Th2 cytokine mixtures onearly gene expression for immune-related molecules by central nervous systemmixed glial cell cultures, Multiple Sclerosis 12 149-168, 2006

Benjamins, JA and Nedelkoska, L. Cyclic GMP dependent pathways protect differentiated oligodendrocytes from multiple types of injury, Neurochem. Res., 32:321-329,

Lisak, RP, Benjamins, JA, Bealmear B., Nedelkoska L, Yao B, Land S, Studzinski D Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures onearly gene expression for glial and neural-related molecules in central nervous system mixed glial cell cultures: neurotrophins, growth factors and structuralproteins. J. Neuroinflammation. Dec 18;4:30

Rose JJ, Bealmer B, Nedelkoska L, Studzinski D, Lisak RP, Benjamins JA. Cytokines decrease expression of interleukin-6 signal transducer and leptin receptor in central nervous system glia. J Neurosci Res Nov q;87(14):3098-106, 2009.

Lisak RP, Benjamins JA, Bealmear B, Nedelkoska L, Studzinski D, Retland E, Yao B, Land S. Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for molecules associated with metabolism, signaling and regulation in central nervous system mixed glial cell cultures. J Neuroinflammation. 2009 Jan 21;

Benjamins, JA, Murphy E and Seyfried T, Lipids.In Basic Neurochemistry, 8th ed. Eds. G.J. Siegel, R.W. Albers, S.T. Brady and D.L. Price; Elsevier Inc., San Diego CA, 2011, pp. 81-100.

Lisak RP, Nedelkoska L, Studzinski D, Bealmear B, Xu W, Benjamins JA.. Cytokines regulate neuronal gene expression: Differential effects of Th1, Th2 and monocyte/macrophage cytokines. J Neuroimmunol. 2011 Jul 29.

Paffen CL, Hooge IT, Benjamins JS, Hogendoorn H. A search asymmetry for interocular conflict. Atten Percept Psychophys. 2011 May;73(4):1042-53.

Benjamins JA, Nedelkoska L, Lisak RP, Hannigan JH, Sokol RJ. Cytokines reduce toxic effects of ethanol on oligodendroglia. Neurochem Res 36:1677-1686 (2011).

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