Otto Muzik, Ph.D.
Otto Muzik, Ph.D.
Dr. Muzik is a medical physicist who was recruited from the University of Michigan in 1993 to assume the role of a senior physicist in the newly opened Children's Hospital of Michigan PET Center. Since then he established himself as an expert in the kinetic analysis of PET data as well as through his work in the development of image analysis software for integrative analysis of pediatric imaging data. Dr. Muzik is also in charge of the microPET/CT core facility at the WSU Medical School.
Dr. Muzik's research interests include the quantitative analysis of oxidative metabolism in Brown Adipose Tissue (BAT) with the objective to establish the relationship between BAT thermogenesis and uptake of FDG, a widely used (but indirect) measure of brown fat metabolism. In addition, Dr. Muzik's research includes the development of methods that allow quantitative integration of multimodality neuroimaging data obtained from PET, MR, fMRI and DTI modalities with special focus on the quantitative assessment of fiber tract connectivity between PET and ECoG-abnormal brain regions in children with epilepsy.
GraduateUniversity of Vienna, Austria, PhD in 1989
Position TitleProfessor of Pediatrics and Radiology
University of Michigan, Cardiac PET Group, 1990-1993
Staff PET physicist, Nuclear Research Center Julich, Nordrhein-Westfalen, Germany, 1989-1990
Kinetic modeling, functional PET imaging in the brain and myocardium, quantitative assessment of Brown Fat metabolism, quantification of myocardial perfusion, clinical applications of advanced multimodality imaging techniques for pre-surgical evaluation of epilepsy patients, microPET imaging in newborns and in preclinical models.
Muzik O, Mangner TJ, Granneman JG. Assessment of oxidative metabolism in brown fat using PET imaging. Front Endocrinol (Lausanne). 2012; 3:15.
Muzik O, Pai D, Juhasz C, Hua J. The need for clinical quantification of combined PET/MRI data in pediatric epilepsy. Nucl Instr Meth Phys Res A 2012; 702: 42-46.
Ren W, Muzik O, Jackson N, Khoury B, Shi T, Flynn JC, Chakraborty P, Markel DC. Differentiation of septic and aseptic loosening by PET with both 11C-PK11195 and 18F-FDG in rat models. Nucl Med Commun. 2012; 33: 747-56.
Gray LW, Peng F, Molloy SA, Pendyala VS, Muchenditsi A, Muzik O, Lee J, Kaplan JH, Lutsenko S. Urinary copper elevation in a mouse model of Wilson's disease is a regulated process to specifically decrease the hepatic copper load. PLoS One 2012; 7: e38327.
Kumar A, Muzik O, Shandal V, Chugani D, Chakraborty P, Chugani HT. Evaluation of age-related changes in translocator protein (TSPO) in human brain using 11C-[R]-PK11195 PET. J Neuroinflammation. 2012 Oct 4; 9: 232.
Juhasz C, Nahleh Z, Zitron I, Chugani DC, Janabi MZ, Bandyopadhyay S, Ali-Fehmi R, Mangner TJ, Chakraborty PK, Mittal S, Muzik O. Tryptophan metabolism in breast cancers: Molecular imaging and immunohistochemistry studies. Nucl Med Biol 2012; 39: 926-932.
Cai H, Mangner TJ, Muzik O, Lu X, Chakraborty PK, Chugani DC, Chugani HT. Fully automated production of 11C-doxepin for PET imaging histamine H1 receptor. Mol Imag Biol 2012;14: 546-52.
Alkonyi B, Barger GR, Mittal S, Muzik O, Chugani DC, Bahl G, Robinette NL, Kupsky WJ, Chakraborty PK, Juhasz C. Accurate identification of recurrent gliomas from radiation injury by kinetic analysis of alpha-[11C]methyl-L-tryptophan PET. J Nucl Med 2012; 53: 1058-1064.
Brown EC, Muzik O, Rothermel R, Matsuzaki N, Juhasz C, Shah AK, Atkinson MD, Fuerst D, Mittal S, Sood S, Diwadkar VA. Evaluating reverse speech as a control task with language-related gamma activity on electrocorticography. Neuroimage 2012; 60: 2335-2345.
Peng F, Lutsenko S, Sun X, Muzik O. Imaging copper metabolism imbalance in Atp7b (-/-) knockout mouse model of wilson's disease with PET-CT and orally administered 64CuCl2. Mol Imaging Biol. 2012; 14: 600-7.
Alkonyi B, Mittal S, Zitron I, Chugani DC, Kupsky WJ, Muzik O, Chugani HT, Sood S, Juhasz C. Increased tryptophan transport in epileptogenic dysembryoplastic neuroepithelial tumors. J Neurooncol 2012; 107: 365-372.
Alkonyi B, Chugani HT, Muzik O, Chugani DC, Sundaram SK, Kupsky WJ, Batista CE, Juhasz C. Increased L-[1-11C]leucine uptake in the leptomeningeal angioma of Sturge-Weber syndrome: a PET study. J Neuroimaging 2012; 22: 177-183.
Peng F, Lutsenko S, Sun X, Muzik O. Positron emission tomography of copper metabolism in the Atp7b-/- knock-out mouse model of Wilson's disease. Mol Imag Biol 2012;14: 70-8.
Juhasz C, Chugani DC, Barger GR, Kupsky WJ, Chakraborty PK, Muzik O, Mittal S. Quantitative PET imaging of tryptophan accumulation in gliomas and remote cortex: Correlation with tumor proliferative activity. Clin Nucl Med 2012; 37: 838-842.
Chugani HT, Kumar A, Muzik O. GABAA Receptor Imaging With Positron Emission Tomography in the Human Newborn: A Unique Binding Pattern. Pediatr Neurol. 2013; 48(6): 459-62
Muzik O, Mangner TJ, Leonard WR, Kumar A, Janisse J, Granneman JG. 15O PET measurement of blood flow and oxygen consumption in cold-activated human brown fat. J Nucl Med. 2013; 54(4): 523-31
Member of the NOIT (Neuroscience and Ophthalmic Technologies) Study Section
Member of the ZRG1 ETTN-G (13) B (Molecular and Cellular Neuroscience, Development and Aging) Study Section
Review Editorial Board of Frontiers in Biomedical Physics