Dr. Ryan Castoro's Laboratory

Peripheral Neuron Axonal Degeneration Lab

Dr. Castoro's lab is a translational neuroscience lab which focuses on developing peripheral nerve imaging techniques to detect axonal loss. Additionally, we study how an epigenetic modification known as DNA methylation regulates peripheral neuron degeneration. All of our studies involve human subject research as well as in-vivo and in-vitro models of peripheral nerve and motor neuron diseases. We collaborate with groups across the world and are always looking for new collaborations. Additionally, we are excited to share our passion for peripheral nerve biology with learners at all levels. For more information please email us directly at: hg0117@wayne.edu

Mouse Sciatic Nerve Ex-vivo: Three month old wild type nerve imaged suspended in PBS on a hollowed agar platform.  Top: Raw image, Bottom: whole nerve outline in red, fascicles outlined in yellow.    Imaged using Verasonic 64LE beamformer, with Verasonics 35-16vX transducer.  Castoro Lab 2022	Mouse Sciatic Nerve In-vivo: Three month old wild type nerve imaged in the left proximal leg.  Top: Raw image, arrowheads point towards fascicles, star = femur Bottom: whole nerve outline in red, fascicles outlined in yellow.    Imaged using Verasonic 64LE beamformer, with Verasonics 35-16vX transducer.  Castoro Lab 2022