Ryan Castoro, D.O.

Ryan Castoro, D.O.

Ryan Castoro, D.O.

Office Address

4201 St. Antoine, Suite 8D - UHC, Detroit, MI 48201

Office Phone: 313 577-1245
Clinic Appointments: (313) 745-4275
Fax Number: (313) 745-4216

Narrative Bio

Dr. Castoro is an Assistant Professor in the Department of Neurology here at Wayne State University. He completed his undergraduate studies at Baylor University. Afterwards, he went to MD Anderson Cancer Center in Houston, TX to study DNA methylation in development and oncogenesis. He then received his medical degree from Oklahoma State University College of Osteopathic Medicine and completed his residency in Physical Medicine and Rehabilitation at Vanderbilt University Medical Center. He then completed his Fellowship at Wake Forest School of Medicine in Neuromuscular Medicine with an emphasis on neuromuscular ultrasound in 2020.

His primary research interest is genetic and epigenetic alterations which lead to peripheral nerve axon degeneration in peripheral nerve disorders. We use both a basic approach and clinical/imaging modalities to study this question with the goal of improving clinical outcomes in patients with peripheral nerve disorders.

His clinical interests are amyotrophic lateral sclerosis (ALS), peripheral neuropathies, Charcot-Marie-Tooth disease, chemotherapy induced neuropathies, hereditary motor neuropathies (HMN) progressive muscular atrophy (PMA) and other neuromuscular disorders.

Department URL



 Bachelor of Science, Biology, Baylor University 2004 - 2006 


 Masters of Medical Sciences, University of North Texas, College of Medicine, August of 2010 - 2011


 Doctor of Osteopathy, D.O., Oklahoma State University, College of Osteopathic Medicine, 2011 - 2015

Position Title

Assistant Professor, Department of Neurology


 Residency - Vanderbilt University Medical Center, Department of Physical Medicine and Rehabilitation, 2015 - 2019


 Neuromuscular Fellowship, Wake Forest University Baptist Medical Center 2019 -  2020


Clinical interests are amyotrophic lateral sclerosis (ALS), peripheral neuropathies, Charcot-Marie-Tooth disease, chemotherapy induced neuropathies, hereditary motor neuropathies (HMN) progressive muscular atrophy (PMA) and other neuromuscular disorders.


 1: Caress JB, Castoro RJ, Simmons Z, Scelsa SN, Lewis RA, Ahlawat A, Narayanaswami P. COVID-19-associated Guillain-Barré syndrome: The early pandemic experience. Muscle Nerve. 2020 Oct;62(4):485-491. doi: 10.1002/mus.27024. Epub
2020 Aug 11. PMID: 32678460; PMCID: PMC7405390.

2: Castoro R, Crisp J, Caress JB, Li J, Cartwright MS. Segmental nerve enlargement in CMT4J. Muscle Nerve. 2020 Jun;61(6):E44-E46. doi: 10.1002/mus.26873. Epub 2020 Apr 4. PMID: 32239724.

3: Pridmore M, Castoro R, McCollum MS, Kang H, Li J, Dortch R. Length-dependent MRI of hereditary neuropathy with liability to pressure palsies. Ann Clin Transl Neurol. 2020 Jan;7(1):15-25. doi: 10.1002/acn3.50953. Epub 2019 Dec 24. PMID: 31872979; PMCID: PMC6952310.

4: Castoro R, Simmons M, Ravi V, Huang D, Lee C, Sergent J, Zhou L, Li J. <i>SCN11A</i> Arg225Cys mutation causes nociceptive pain without detectable peripheral nerve pathology. Neurol Genet. 2018 Jul 20;4(4):e255. doi: 10.1212/NXG.0000000000000255. PMID: 30046661; PMCID: PMC6055356.

5: Hu B, McCollum M, Ravi V, Arpag S, Moiseev D, Castoro R, Mobley B, Burnette B, Siskind C, Day J, Yawn R, Feely S, Li Y, Yan Q, Shy M, Li J. Myelin abnormality in Charcot-Marie-Tooth type 4J recapitulates features of acquired demyelination. Ann Neurol. 2018 Apr;83(4):756-770. doi: 10.1002/ana.25198. Epub
2018 Mar 30. PMID: 29518270; PMCID: PMC5912982.

6: Hu B, Wang M, Castoro R, Simmons M, Dortch R, Yawn R, Li J. A novel missense mutation in AIFM1 results in axonal polyneuropathy and misassembly of OXPHOS
complexes. Eur J Neurol. 2017 Dec;24(12):1499-1506. doi: 10.1111/ene.13452. Epub 2017 Oct 7. PMID: 28888069; PMCID: PMC5693754.

7: Maegawa S, Gough SM, Watanabe-Okochi N, Lu Y, Zhang N, Castoro RJ, Estecio MR, Jelinek J, Liang S, Kitamura T, Aplan PD, Issa JP. Age-related epigenetic drift in the pathogenesis of MDS and AML. Genome Res. 2014 Apr;24(4):580-91.doi: 10.1101/gr.157529.113. Epub 2014 Jan 10. PMID: 24414704; PMCID: PMC3975058.

8: Boumber Y, Kantarjian H, Jorgensen J, Wen S, Faderl S, Castoro R, Autry J,Garcia-Manero G, Borthakur G, Jabbour E, Estrov Z, Cortes J, Issa JP, Ravandi F.A randomized study of decitabine versus conventional care for maintenance therapy in patients with acute myeloid leukemia in complete remission. Leukemia. 2012 Nov;26(11):2428-31. doi: 10.1038/leu.2012.153. Epub 2012 Jun 5. PMID:22665218; PMCID: PMC3981542.

9: Bhardwaj A, Song HW, Beildeck M, Kerkhofs S, Castoro R, Shanker S, De Gendt K, Suzuki K, Claessens F, Issa JP, Orgebin-Crist MC, Wilkinson MF. DNA demethylation-dependent AR recruitment and GATA factors drive Rhox5 homeobox gene transcription in the epididymis. Mol Endocrinol. 2012 Apr;26(4):538-49. doi: 10.1210/me.2011-1059. Epub 2012 Feb 9. PMID: 22322598; PMCID: PMC3327359.

10: Konishi K, Watanabe Y, Shen L, Guo Y, Castoro RJ, Kondo K, Chung W, Ahmed S, Jelinek J, Boumber YA, Estecio MR, Maegawa S, Kondo Y, Itoh F, Imawari M, Hamilton SR, Issa JP. DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis. PLoS One. 2011;6(11):e27889. doi: 10.1371/journal.pone.0027889. Epub 2011 Nov 21. PMID: 22132162; PMCID:

11: Qin T, Castoro R, El Ahdab S, Jelinek J, Wang X, Si J, Shu J, He R, Zhang N, Chung W, Kantarjian HM, Issa JP. Mechanisms of resistance to decitabine in the myelodysplastic syndrome. PLoS One. 2011;6(8):e23372. doi: 10.1371/journal.pone.0023372. Epub 2011 Aug 17. PMID: 21858090; PMCID: PMC3157379.

12: Watanabe Y, Castoro RJ, Kim HS, North B, Oikawa R, Hiraishi T, Ahmed SS, Chung W, Cho MY, Toyota M, Itoh F, Estecio MR, Shen L, Jelinek J, Issa JP. Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer. PLoS One. 2011;6(8):e23320. doi: 10.1371/journal.pone.0023320. Epub 2011 Aug 11. PMID: 21853109; PMCID: PMC3154922.

13: Estécio MR, Gallegos J, Vallot C, Castoro RJ, Chung W, Maegawa S, Oki Y, Kondo Y, Jelinek J, Shen L, Hartung H, Aplan PD, Czerniak BA, Liang S, Issa JP. Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer. Genome Res. 2010 Oct;20(10):1369-82. doi: 10.1101/gr.107318.110. Epub 2010 Aug 17. PMID: 20716667; PMCID: PMC2945186.

14: Watanabe Y, Kim HS, Castoro RJ, Chung W, Estecio MR, Kondo K, Guo Y, Ahmed SS, Toyota M, Itoh F, Suk KT, Cho MY, Shen L, Jelinek J, Issa JP. Sensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes. Gastroenterology. 2009 Jun;136(7):2149-58. doi: 10.1053/j.gastro.2009.02.085. Epub 2009 Apr 16. PMID: 19375421; PMCID:

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