Bo Hu, PhD

Bo Hu, PhD

bhu@med.wayne.edu

313-577-1586

Bo Hu, PhD

Narrative Bio

Dr. Bo Hu is an Assistant Professor (Research) of the Department of Neurology at Wayne State University School of Medicine. He received his MD and PhD degrees from University of South China. He joins us in May 2018 from Vanderbilt University where he become a faculty member as a Research Instructor following completing his postdoctoral training with mentor Dr. Jun Li.

Office Address

421 E. Canfield St,
2128 Elliman Building,
Detroit MI, 48201

Links of Interest

Research Summary:

Dr. Hu’s research interests are inherited peripheral nerve diseases and Schwann cell–axon interaction in myelin physiopathology. He is focused on investigating the mechanisms that extrinsic signals from FIG4-deficient axons and macrophages exacerbate the overload of cytoplasmic calcium in Schwann cells, leading to segmental demyelination by utilizing mouse models with constitutive and conditional knockout of Fig4. He has performed research on how increase of intracellular calcium in myelinating Schwann cells drives the cells toward a dedifferentiation state and calcium chelator suppresses the dedifferentiation and demyelination in vitro and in vivo models. He has investigated PAK1 signaling pathway which is responsible for the disruption of myelin junctions and PAK1 inhibitor rescues phenotypes of Hereditary Neuropathy with Pressure Palsies.

Awards & Honors

CMTA travel award, Charcot-Marie-Tooth Association, USA, 2016.

Academic Rank

Assistant Professor, Department of Neurology (Research)

Graduate

University of South China, Ph.D., 2008-2011
University of South China, M.Sc., 2004-2007

Position Title

Assistant Professor, Department of Neurology (Research)

Medical

University of South China, M.D., 1998-2003

Fellowships

Post-doctoral Research Fellow, Department of Neurology, Vanderbilt University School of Medicine, 2012-2017

Prior Appointments

 Research Instructor, Department of Neurology, Vanderbilt University School of Medicine. 2017-2018

Interests

Inherited peripheral nerve diseases, myelin biology and disorders

Publications

 (SELECTED)
Peer-Reviewed Journal Articles:
1. Hu B, McCollum M, Ravi V, Arpag S, Moiseev D, Castoro R, Mobley B, Burnette B, Siskind C, Day J, Yawn R, Feely S, Li Y, Yan Q, Shy M, Li J. Myelin abnormality in Charcot-Marie-Tooth type 4J recapitulates features of acquired demyelination. Ann Neurol, 2018, 83(4):756-770.
2. Moiseev D, Hu B, Li J. Morphometric analysis of peripheral myelinated nerve fibers through deep learning. J Peripher Nerv Syst. 2018. [Epub ahead of print]
3. Hu B, Wang M, Castoro R, Simmons M, Dortch R, Yawn R, Li J. A novel missense mutation in AIFM1 results in axonal polyneuropathy and misassembly of OXPHOS complexes. Eur J Neurol, 2017, 24(12):1499-1506.
4. Hu B, Arpag S, Zhang X, Möbius W, Werner H, Sosinsky G, Ellisman M, Zhang Y, Hamilton A, Chernoff J, Li J. Tunig PAK activity to rescue abnormal myelin permeability in HNPP. Plos Genetics, 2016, 12(9):e1006290.
5. Bo Hu, Sezgi Arpag, Brett Parker, Robin Yawn, Jane Howard, Bryan Burnette, Stephan Zuchner, Jun Li. A Novel Missense Mutation of LRSAM1 causes CMT2P and Alters Transcription Machinery. Ann Neurol, 2016, 80(6):834-845.
6. Zou J, Hu B (Co-first-author), Arpag S, Yan Q, Hamilton A, Zeng YS, Vanoye CG, Li J. Reactivation of Lysosomal Ca2+ Efflux Rescues Abnormal Lysosomal Storage in FIG4-Deficient Cells. J Neurosci. 2015, 35(17):6801-6812.
7. Guo J, Wang L, Zhang Y, Wu J, Arpag S, Hu B, Imhof BA, Tian X, Carter BD, Suter U, Li J. Abnormal junctions and permeability of myelin in PMP22-deficient nerves. Ann Neurol, 2014, 75(2):255-265.

Peer-Reviewed Conference Proceedings:
1. Isaac Manzanera, Megan Simmons, Daniel Moiseev, Bo Hu, Jun Li, Richard Dortch. Quantitative MRI of Nerve Pathology in Mouse Models of CMT1A and HNPP. April 21, 2018; 2018 American Academy of Neurology, Los Angeles.
2. Bo Hu, Sezgi Arpag, Stephan Zuchner, Jun Li. A Novel CMT2P Missense Mutation in the ring domain of LRSAM1 impairs nuclear translacation of RNA-bingding proteins. July 2017. 2017 Peripheral Nerve Society annual meeting, Spain.
3. Bo Hu, Sezgi Arpag, Brett Parker, Robin Yawn, Jane Howard, Bryan Burnette, Stephan Zuchner, Jun Li. A Novel Missense Mutation of LRSAM1 causes CMT2P and Alters Transcription Machinery. April 2017. Vanderbilt Postdoctoral Association & Shared Resources Symposium, Nashville, TN.
4. Hu B, Arpag S, Zhang X, Möbius W, Werner H, Sosinsky G, Ellisman M, Zhang Y, Hamilton A, Chernoff J, Li J. Tuning actin polymerization to rescue abnormal myelin permeability in HNPP. 6th International Charcot‐Marie‐Tooth and Related Neuropathy Consortium (CMTR) Meeting. September 8–10, 2016, Venice-Mestre, Italy.
5. Li J, Arpag S, Hu B. Impaired Nerve Conduction Relating to the Altered Ratio of Non-compact Region Over Compact Region of Myelin. 6th International Charcot‐Marie‐Tooth and Related Neuropathy Consortium (CMTR) Meeting. September 8–10, 2016, Venice-Mestre, Italy.
6. Hu B, Arpag S, Zhang X, Möbius W, Werner H, Sosinsky G, Ellisman M, Zhang Y, Hamilton A, Chernoff J, Li J. Tuning PAK Activity to Rescue Abnormal Myelin Permeability in HNPP. April 2016. Vanderbilt Postdoctoral Association & Shared Resources Symposium, Nashville, TN.
7. Bo Hu, Sezgi Arpag, Yang Zhang, Xuebao Zhang, Audra Hamilton, Jonathan Chernoff, Jun Li. Tuning p-21-Activated Kinase to Rescue Abnormal Myelin Permeability in HNPP. July 2015. 2015 Peripheral Neuropathy Association meeting, Canada.
8. Bo H, Yan Q, Li J. Segmental Demyelination in Fig4 Deficiency. Apr. 2014, 2014 American Academy of Neurology, Philadelphia, PA, USA.
9. Bo Hu, Jiasong Guo, Yang Yang, Leiming Wang, Jiawen Wu, Sezgi Arpag, Bruce Carter, Ueli Suter. Disruption of Myelin Junctions and Increase of Myelin Permeability in PMP22 Deficiency. Apr. 2014, 2014 American Academy of Neurology, Philadelphia, PA, USA.

 

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