School of Medicine

Wayne State University School of Medicine

Faculty Profile

Csaba Juhasz
Title
Professor of Pediatrics and Neurology, PET Center, Children's Hospital of Michigan
Phone
313-966-5136
Profile

Csaba Juhasz, M.D., Ph.D. is a Professor of Pediatrics and Neurology at Wayne State University School of Medicine. He is also a member of the Karmanos Cancer Institute. He previously was a faculty member of the Department of Neurology at the Semmelweis University in Budapest, Hungary, between 1994 and 2000, where he was involved in clinical work and research in epilepsy, clinical electrophysiology, stroke and neurology intensive care. He was a visiting research fellow at the Department of Neurophysiology at the University of California, Los Angeles in 1994-1995. After completing a postdoctoral fellowship at the Positron Emission Tomography (PET) Center, Children's Hospital of Michigan (CHM), he became an assistant professor of Pediatrics and Neurology at WSU in 2001. He received his PhD from epilepsy imaging in 2002. He was promoted to associate professor in 2008 and to full professor in 2013.

Dr. Juhasz's research interests are in functional and structural neuroimaging of epilepsy, brain tumors and developmental brain disorders, with a particular interest in the pathophysiology and progression of Sturge-Weber syndrome. He performed extensive research applying multimodal neuroimaging, combining magnetic resonance imaging techniques with PET imaging using various radiotracers to measure brain glucose metabolism, benzodiazepine receptor binding and tryptophan metabolism. He has also combined these techniques with EEG to improve localization of epileptic foci in patients with medically uncontrolled epilepsy and provides multimodal imaging support to the pediatric epilepsy surgery program at CHM. Dr. Juhasz has been the principal investigator of several R01 grant projects funded by the National Institutes of Health to study progression of brain structural and functional abnormalities in Sturge-Weber syndrome and to explore the clinical use of tryptophan PET imaging in the detection and monitoring of brain tumors and extracerebral cancers.

Graduate
Semmelweis University, Medical School, Budapest, Hungary, Ph.D., 2002
Medical

University School Pecs, Hungary, M.D., 1989

Residency
University Medical School, Pecs, Hungary (Neurology), 1989-1993
Fellowships

Department of Neurology, University Medical School, Pecs, Hungary, 1989-1993

PET Imaging, Children's Hospital of Michigan, 1998-2001; University of California, Los Angeles, Clinical Neurophysiology, 1994-1995

Postdoctoral Fellow, PET Imaging, Wayne State University, Detroit, MI 1998-2001

Prior Appointments

Associate Professor of Neurology, Semmelweis Medical University. Budapest, Hungary, 1997-2000

Assistant Professor of Neurology, Semmelweis Medical University, Budapest, Hungary, 1994-1997

Interests

Functional neuroimaging, PET scanning, clinical applications of advanced multimodality imaging techniques, epilepsy pre-surgical evaluation, Sturge-Weber syndrome, brain tumor imaging

Publications

 Selected from 150 full-length publications:

 

Juhasz C, Nagy F, Watson C, da Silva EA, Muzik O, Chugani DC, Shah J, Chugani HT. Glucose and [11C]flumazenil positron emission tomography abnormalities of thalamic nuclei in temporal lobe epilepsy. Neurology 1999;53:2037-2045.

Juhasz C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT. Is epileptogenic cortex truly hypometabolic on interictal positron emission tomography? Ann Neurol 2000;48:88-96.

Juhasz C, Chugani DC, Muzik O, Watson C, Shah J, Shah A, Chugani HT. Electroclinical correlates of flumazenil and fluorodeoxyglucose PET abnormalities in lesional epilepsy. Neurology 2000;55:825-834.

Juhasz C, Chugani DC, Muzik O, Shah A, Asano E, Mangner T, Chakraborty PK, Sood S, Chugani HT. Alpha-methyl-L-tryptophan PET detects epileptogenic cortex in children with intractable epilepsy. Neurology 2003;60:960-968.

Juhasz C, Chugani DC, Muzik O, Wu D, Sloan A, Barger G, Watson C, Shah A, Sood S, Ergun EL, Mangner T, Chakraborty P, Kupsky WJ, Chugani HT. In vivo uptake and metabolism of alpha-[11C]methyl-L-tryptophanin human brain tumors. J Cereb Blood Flow Metab 2006;26:345-57.

Juhasz C, Haacke M, Hu J, Xuan Y, Makki M, Behen ME, Maqbool M, Muzik O, Chugani DC, Chugani HT. Multimodality imaging of cortical and white matter abnormalities in Sturge-Weber syndrome. AJNR Am J Neuroradiol 2007; 28:900-6.

Juhasz C. Lai C, Behen ME, Muzik O, Helder EJ, Chugani DC, Chugani HT. White matter volume as a major predictor of cognitive function in Sturge-Weber syndrome. Arch Neurol 2007;64:1169-74.

Juhasz C, Batista EA, Chugani DC, Muzik O, Chugani HT. Evolution of cortical metabolic abnormalities and their clinical correlates in Sturge-Weber syndrome. Eur J Paediatr Neurol 2007;11:277-84.

Fukuda M, Nishida M, Juhasz C, Muzik O, Sood S, Chugani HT, Asano E. Short-latency median-nerve somatosensory-evoked potentials and induced gamma oscillations in humans. Brain - 2008;131:1793-805.

Nishida M, Juhasz C, Sood S, Chugani HT, Asano E. Cortical glucose metabolism positively correlates with gamma-oscillations in nonlesional focal epilepsy. NeuroImage 2008;42:1275-84.

Juhasz C, Muzik O, Lu X, Jahania S, Soubani AO, Khalaf M, Peng F, Mangner TJ, Chakraborty PK, Chugani DC. Quantification of tryptophan transport and metabolism in lung tumors using positron emission tomography. J Nucl Med 2009; 50:356-63.

Asano E, Juhasz C, Shah A, Sood S, Chugani HT. Role of subdural electrocorticography in prediction of long-term seizure outcome in epilepsy surgery. Brain 2009;132;1038-47.

Juhasz C, Asano E, Shah A, Chugani DC, Muzik O, Sood S, Chugani HT. Focal decreases of cortical GABAA receptor binding remote from the primary seizure focus: what do they indicate? Epilepsia- 2009;50:240-250.

Kumar A, Juhasz C, Asano E, Sood S, Muzik O, Chugani HT. Objective detection of epileptic foci by FDG PET in children undergoing epilepsy surgery. J Nucl Med 2010;51:1901-7.

Juhasz C, Muzik O, Chugani DC, Chugani HT, Sood S, Chakraborty PK, Barger GR, Mittal S.Differential kinetics of alpha-[11C]methyl-L-tryptophan on PET in low-grade brain tumors. J Neurooncol 2011;102:409-415.

Wu J, Tarabishy B  Hu J, Miao Y, Cai Z, Xuan Y, Behen M, Ye Y, Shoskey R, Haacke EM, Juhasz C. Cortical calcification in Sturge-Weber syndrome on MRI-SWI: Relation to brain perfusion status and seizure severity. J Magnetic Res Imaging 2011;34:791-798.

Alkonyi B, Chugani HT, Juhasz C. Transient focal increase of interictal glucose metabolism in Sturge-Weber syndrome: implications for epileptogenesis. Epilepsia 2011;52:1265-1272.

Chugani HT, Kumar A, Kupsky W, Asano E, Sood S, Juhasz C. Clinical and histopathological correlates of 11C-alpha-methyl-L-tryptophan (AMT) PET abnormalities in children with intractable epilepsy. Epilepsia 2011;52:1692-1698.

Juhasz C, Chugani DC, Barger GR, Kupsky WJ, Chakraborty PK, Muzik O, Mittal S. Quantitative PET imaging of tryptophan accumulation in gliomas and remote cortex: Correlation with tumor proliferative activity. Clin Nucl Med 2012;37:838-842.

Juhasz C, Nahleh Z, Zitron I, Chugani DC, Janabi MZ, Bandyopadhyay S, Ali-Fehmi R, Mangner TJ, Chakraborty PK, Mittal S, Muzik O. Tryptophan metabolism in breast cancers: Molecular imaging and immunohistochemistry studies. Nucl Med Biol 2012;39:926-932.

Juhasz C. The impact of positron emission tomography imaging on the clinical management of patients with epilepsy. Exp Rev Neurother 2012;12:719-732.

Kamson DO, Mittal S, Buth A, Muzik O, Kupsky WJ, Robinette NL, Barger GR, Juhasz C. Differentiation of glioblastomas from metastatic brain tumors by tryptophan uptake and kinetic analysis: a PET study with MRI comparison. Mol Imaging 2013;12(5):327-337.

Kamson DO, Juhasz C, Buth A, Kupsky WJ, Barger GR, Chakraborty P, Muzik O, Mittal S. Tryptophan PET in pretreatment delineation of newly-diagnosed gliomas: MRI and histopathologic correlates. J Neurooncol 2013;112:121-32.
sz C. Localization of function-specific segments of the primary motor pathway in children with Sturge-Weber syndrome: A multimodal imaging analysis. J Magn Reson Imaging 2013;38(5):1152-61.

Jeong JW, Chugani HT, Behen ME, Guy W, Juhsz C. Quantitative assessment of brain networks in children with Sturge-Weber syndrome using resting state functional MRI. J Child Neurol 2013;28(11):1448-55.

Henry TR, Juhasz C. Serotonergic PET in temporal lobe epilepsy: Biomarking or etiologic mapping? Neurology 2013;80:1450-1451.

Kamson DO, Mittal S, Robinette NL, Muzik O, Kupsky WJ, Barger GR, Juhasz C. Increased tryptophan uptake on PET has a strong independent prognostic value in patients with a previously treated high-grade glioma. Neuro Oncol 2014;16:1373-1383.

Jeong JW, Asano E, Juhasz C, Chugani HT. Quantification of primary motor pathways using diffusion MRI tractography and its application to predict postoperative motor deficits in children with focal epilepsy. Hum Brain Mapping 2014;35:3216-3226

Juhasz C, Dwivedi S, Kamson DO, Michelhaugh SK, Mittal S. Comparison of amino acid positron emission tomography radiotracers for molecular imaging of primary and metastatic brain tumors. Mol Imaging 2014 DOI 10.2310/7290.2014.00015

Awards & Honors
  • Eotvos Research Scholarship from the Hungarian Ministry of Culture and Education (1994)
  • Invited speaker at the International Conference on Human Brain Mapping (Sendai, Japan, 2002), the International Seoul Epilepsy Conference (2003) and the Annual Meeting of the Korean Epilepsy Society (2007), the Annual Meeting of the American Epilepsy Society (2004, 2010, 2013), International Epilepsy Congresses (Paris, 2005, Singapore, 2007, Budapest, 2009), national Sturge-Weber syndrome conferences (2003, 2005, 2007, 2011, 2013), the Conference on Vascular Anomalies (New York, 2007), the International Conference on the Diagnosis and Therapy in Pediatric Neurology (Poland, 2008), the Advanced Topics in Neurology course at the University of Sao Paulo (Brazil, 2008), 19th International Cleveland Clinic Epilepsy Symposium (2010), Pragua Symposium of Child neurology and Developmental Epileptology (2011), The Annual Scientific Meeting of the International Society for neurovascular Disease (Orlando, 2012), The National Epilepsy Meeting of Hungary (Kaposvar, 2012), The Annual Meeting of the Child Neurology Society (Huntington Beach, 2013), Regional Sturge-Weber Symposium (Dearborn, 2014), ECOG-Acrin Meeting (Orlando, 2014)
  • Wayne State University Career Development Chair Award (2009)
  • The Sturge-Weber Foundation "Champion Award", awarded at the International Sturge-Weber Conference in 2011
  • SOM Teaching Award (2012)
Other Information

Certifications: Board certification in Neurology, Hungarian Board of Neurology, 1993