School of Medicine

Wayne State University School of Medicine

OCT in Other Neurological Disorders

•The retina, when viewed for its structure, holds the potential to be a window into the brain on many neurological disorders.  While information is abundant for MS and increasing for PD, other neurological-linked disorders can still be investigated to increase our understanding and the OCT presents as a high resolution, highly reproducible tool available to do just that.
 
Chronic Relapsing Inflammatory Optic Neuritis (CRION)
•CRION is a rare disorder which presents as an optic neuritis that relapses (worsening of or reoccurrence of the symptoms after a period of improvement) over a period of time, often with severe and lasting effects of vision loss.
 
•Understanding patterns within the OCT outcomes holds the potential to assist in diagnosis or help track progression of patients with CRION. We are currently continuing to follow patients, both after initial attack of ON to see if they have relapses over time, and on patients that have remitting attacks of ON with negative NMO antibodies to assess patterns within the RNFL outcomes.
 
RNFL outcomes for CRION patient. 
Top left: Green circle indicates where the image was taken around the optic nerve head.
Top right: the circular image around the ONH is flattened out and flipped 90 degrees so that all layers of the retina can be observed.  The RNFL is being measured between the two red lines.
Bottom left:  Red coloring within the pie chart is showing significant thinning in all segments, except the nasal, which is borderline below average.
Bottom right: the green section indicates the average thickness of the RNFL associated with this person’s age group, the black line indicates the actual thickness of the RNFL for this person.
 
 
 
Alzheimer’s Disease
•In Alzheimer’s disease, we are investigating the potential to find biomarkers within the retina that will aid in early diagnosis of the disease.  As a disease that requires a diagnosis of exclusion, having a tool which could assist in early diagnosis will be beneficial for treatment and control of the development of the disease.  If a trend is found, OCT may also prove useful as a secondary outcome to see the efficacy of medications and treatments over time.
 
Pediatrics
•While OCT has become a useful tool in the MS population in adult patients, this technique has not been used to examine children with acute demyelinating encephalomyelitis (ADEM), isolated optic neuritis or transverse myelitis and thus comparisons based on adult and pediatric onset forms have not been made. Comparisons between age populations have also not been made in individuals with MS or NMO. We plan to collect data on patients over time and correlate with disease severity and progression.
 
 

32 line image 3D- reconstruction of swelling of the optic nerve head