School of Medicine

Wayne State University School of Medicine

Faculty Profile

Aashit K. Shah, M.D.
Title
Associate-Chair and Professor of Neurology
Chief of Neurology - Harper Hospital
Director of Clinical Neurophysiology (Holden Lab)
Phone
313-577-1244
Profile

Aashit K. Shah, M.D., is a Associate-Chair and Professor of Neurology, is the Director of the WSU/Detroit Medical Center Comprehensive Epilepsy Program. He is the Program Director of the Clinical Neurophysiology fellowship and an active member of the Adult Comprehensive Epilepsy Program at Wayne State University/ Detroit Medical Center and Chief of Neurology - Harper Hospital. Dr. Shah joined the department as a resident in 1989 and obtained fellowship training in Clinical Neurophysiology also at the same program. Following the training in 1993 he was appointed as Assistant Professor of Neurology. He served as the Residency Program coordinator from 1997 to 2003. He is serving as the Program Director of the Clinical Neurophysiology fellowship program since 2006. He also serves as a director of the EEG lab at Harper University Hospital and has served as the Lab Director for Children’s Hospital of Michigan for several years between 200 and 2004.

Dr. Shah is a specialist in treatment of epilepsy. He works closely with several other epileptologists as well as other clinicians and researchers with various expertises in related fields. His primary areas of research and clinical interests are in epilepsy and clinical neurophysiology, including medically intractable epilepsy, epilepsy surgery, quantitative electrophysiology, and EEG monitoring in ICU. His clinical interest also focuses on women’s issues in neurology and neurological disorders and their management during pregnancy, specifically eclampsia. He is conducting several phase 3 clinical trials for treatment of epilepsy. Over the years, his work has been funded by the research grants from NIH as well as by pharmaceutical companies.

Medical
Smt. N.H. L. Municipal Medical College, Gujarat University, India, M.B.B.S., 1987
Internship
Interfaith Medical Center, Brooklyn, NY, 1988-1989
Residency
Wayne State University/ Detroit Medical Center, Detroit, 1989-1992
Fellowships
Clinical Neurophysiology, Wayne State University/ Detroit Medical Center, 1992-1993
Interests

Clinical Neurophysiology (EEG), Epilepsy surgery, Intractable epilepsy and its treatment, Neurology of pregnancy, ICU EEG monitoring

Publications

Shah AK. Non-aneurysmal primary subarachnoid hemorrhage in pregnancy-induced hypertension and eclampsia. Neurology 2003;61:117-120.

Shah AK, Agarwal R, Carhuapoma JR, Loeb JA. Compressed EEG Pattern Analysis for Critically Ill Neurological-Neurosurgical Patients. Neurocrit. Care 2006;05:124-133.

Rakhade SN, Shah AK, Agarwal R, Yao Bin, Asano E, Fuerst Darren, Loeb JA. Activity-Dependent Gene Expression Correlates with Interictal Spiking in Human Neocortical Epilepsy. Epilepsia 2007; 48 (suppl 5):86-95.

Shah AK, Fuerst D, Sood S, Asano E, Ahn-Ewing J, Pawlak C, Chugani HT. Seizures lead to elevation of intracranial pressure (ICP) in children undergoing invasive EEG monitoring. Epilepsia 2007; 48(6):1097–1103.

Haseeb A, Asano E, Juhasz C, Shah A, Sood S, Chugani HT. Young patients with focal seizures may have the primary motor area for the hand in the postcentral gyrus. Epilepsy Research 2007; 76:131-139.

Shah AK, Atkinson MD, Loeb JA, Watson CE, Mittal S. Intraoperative hippocampal electrocorticography following temporal neocortex resection exhibits frequent electrographic seizures. Epilepsia 2007; 48(suppl 6):128.

Shah AK, Rajamani K, Whitty JE. Eclampsia: A neuroloigcal perspective. Journal of Neurological Sciences. J Neurol Sci. 2008;271(1-2):158-67

Juhász C, Asano E, Shah A, Chugani DC, Batista CE, Muzik O, Sood S, Chugani HT. Focal decrease of cortical GABA A receptor binding remote from the primary seizure focus: What do they indicate? Epilepsia 2008; (in press)

Shah AK, Atkinson MD, Rayes M, Zitron IM, Loeb JA, Watson CE, Mittal S. Selective intraoperative hippocampal electrocorticography (IH-ECoG) following temporal neocortical resection reveals frequent electrographic seizures. CNS 2008 (in press)

Shah AK, Atkinson M, Kupsky W,Mittal S. Relationship of seizures recorded during intraoperative hippocampal electrocorticography and hippocampal pathology. Epilepsia 2008 (in press)

Basha MM, Shah AK, Fuerst D, Mittal S. Relationship of tumor and epileptogenic zone in patients with tumor-related epilepsy evaluated with prolonged intracranial EEG monitoring. SNO meeting 2008 (in press)

Tran Y, Atkinson M, Coplin W, Norris G, Casey K, Shah AK. Should Early Surgical Intervention Be Used More Often in Prolonged Refractory Status Epilepticus? Epilepsia 2008 (in press)

Shah AK: Myasthenia Gravis. eMedicine Neurology Online Reference. eMedicine, Inc., St. Pete Beach.

Shah AK: Preeclampsia and Eclampsia. eMedicine Neurology Online Reference. eMedicine, Inc, St. Pete Beach.

Awards & Honors
  • Gold Medal awarded for "The Best Outgoing Student of the Year", Smt NHL Muni Medical College, Gujarat University, 1986
  • Gold Medal awarded by Rotary Club of Ahmedabad for Highest score in Final MBBS
  • Recipient of Wayne State University College Teaching Award
  • Best Doctor’s in America: Midwest region
  • Who’s Who in Medicine and Health Care
  • Who’s Who in America Science and Engineering
  • Who’s Who in America
  • Who’s Who in World
  • Best Doctors in America
  • Best Doctors in Michigan
Other Information

New research funded in 2011

"Double-Blind, Randomized, Historical Control Study of the Safety and Efficacy of Eslicarbazepine Acetate Monotherapy in Subjects with Partial Epilepsy Not Well Controlled by Current Antiepileptic Drug.” Sponsor: Sunovion Pharmaceuticals, Inc. Aashit Shah, PI.

 
“Electrical, Molecular and Clinical Correlates of Human Interictal Spiking.” Sponsor: National Institute of Neurological Disorders and Stroke. Aashit Shah, PI.
 
“Correlation of Plasma and Cerebrospinal Fluid (CSF) Levels of Lacrosamise (LCM).” Sponsor: UCB Pharma. Aashit Shah, PI.
 
“A Randomized Double Blind Placebo Controlled Study of the Safety and Efficacy of Intranasal Midazolam (USL 261) in the Outpatient Treatment of Subjects with Seizure Clusters.’ Sponsor: Pharmanet, Inc. Aashit Shah, PI.