School of Medicine

Wayne State University School of Medicine

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Senthil K. Sundaram
Title
Assistant Professor of Pediatrics and Neurology, PET Center Children's Hospital of Michigan
Phone
313-993-2870
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Dr. Sundaram went to the medical school at Thanjavur in Tamil Nadu, India. He was selected for the nuclear medicine residency program at All India Institute of Medical Sciences (AIIMS), the premier medical institution in India. Immediately after finishing his residency, he was awarded the International Visiting Fogarty Fellowship at National Institutes of Health (NIH). At NIH Dr. Sundaram developed a new quantitative model of FDG study, called Simplified Kinetic Analysis and worked in the field of PET qualification.

At the PET center at WSU Dr. Sundaram recently demonstrated that in developmentally delayed children with normal conversational MRI scans, the arcuate fasciculus (language pathway) is entirely absent in about half of patients studied using Diffusion Tensor Imaging (DTI). This finding seems to suggest that adequate maturation of language pathways is an important precondition for higher cognitive functions to emerge. Dr. Sundaram has recently used this imaging finding as an endophenotype to identify the genetic causes behind developmental delay. In particular, sequencing the axon guidance genes and genome wide SNP analysis are being used to identify the genetic causes behind developmental delay.

Dr. Sundaram went to the medical school at Thanjavur in Tamil Nadu, India. He was selected for the nuclear medicine residency program at All India Institute of Medical Sciences (AIIMS), the premier medical institution in India. Immediately after finishing his residency.

Graduate
Thanjavur Medical College, India, MBBS, 1996
Medical

All India Institute of Medical Sciences, New Delhi, India, M.D., 2000

Internship

Thanjavur Medical College, Thanjavur, Tamil Nadu, India, 1996-1997

Residency

All India Institute of Medical Sciences, New Delhi, India, India (Nuclear Medicine), 1997-2000

Fellowships

Visiting Fellow, University of Wisconsin, Nuclear Medicine, 2003-2004

National Institutes of Health, PET, Bethesda, MD, 2000-2003

Interests

Developmental delay autism, neuroimaging, genetics

Publications

Kumar A, Sundaram SK, Sivaswamy L, Makki MI, Behen ME, Chugani HT, Chugani DC. Frontal lobe association tracts in autism spectrum disorder: A diffusion tensor imaging study. (Manuscript in preparation)

Govindan RM, Makki MI, Sundaram SK, Juhasz C, Chugani HT. Diffusion tensor analysis of temporal and extra-temporal lobe tracts in temporal lobe epilepsy. Epilepsy Res. 2008 Jul;80(1):30-41. Epub 2008 Apr 233.

Sundaram SK, Kumar A, Makki MI, Behen ME, Chugani HT, Chugani, DC. Diffusion Tensor Imaging of Frontal Lobe in Autism Spectrum Disorder. Cereb Cortex. 2008 Nov;18(11):2659-65. Epub 2008 Mar 20.

Sundaram SK, Sivaswamy L, Makki MI, Behen ME, Chugani HT. 2008. Absence of arcuate fasciculus in children with global developmental delay of unknown etiology: a diffusion tensor imaging study. J Pediatr. 152:250-255.

Sundaram SK, Muzik O, Chugani DC, Mu F, Mangner TJ, Chugani HT. Quantification of protein synthesis in the human brain using L-[1-11C]-leucine PET: incorporation of factors for large neutral amino acids in plasma and for amino acids recycled from tissue.J Nucl Med. 2006 Nov;47(11):1787-95.

Sundaram SK, Chugani HT, Chugani DC. PET Methods with Potential for Increased Understanding of Mental Retardation and Developmental Disabilities. Mental retardation and Developmental Disabilities Review. Ment Retard Dev Disabil Res Rev. 2005;11(4):325-30.

Sundaram SK, Freedman NMT, Carrasquillo JA, Carson JM, Whatley M, Libutti SK, Sellers D, and Bacharach SL. Simplified Kinetic Analysis of Tumor 18F-FDG Uptake: A Dynamic Approach. Journal of Nuclear Medicine, 45: 1328-1333, 2004.

James H. Holmes, Ronald L. Sorkness, Sara K. Meibom, Senthil K. Sundaram, Scott B. Perlman, Alexander K. Converse, Robert W. Pyzalski, Andrew D. Hahn, Frank R. Korosec, Thomas M. Grist, Sean B. Fain. Noninvasive mapping of regional response to segmental allergen challenge using magnetic resonance imaging and [F-18]fluorodeoxyglucose positron emission tomography. Magn Reson Med. 2005 Jun;53(6):1243-50.

Nanette MT Freedman, Senthil K. Sundaram, Karen Kurdziel, Jorge A Carrasquillo, Millie Whatley, Joann M Carson, David Sellers, Steven K Libutti, James C Yang, Stephen L Bacharach. Comparison of SUV and patlak slope to monitor cancer therapy using serial PET scans. European Journal of Nuclear Medicine and Molecular Imaging, 46 - 53, 30(1), 2003.

Stephen L Bacharach, Senthil K. Sundaram. FDG in Cardiac and Oncologic Imaging: The bitter with the sweet. Journal of Nuclear Medicine.1542-1544, 43(11), 2002.

Senthil K. Sundaram, Bal C S. Radionuclide cisternography. Indian Journal of Nuclear Medicine, 23-26; 15(1):2000.

Bal C S, Senthil K. Sundaram. Radionuclide studies in Pediatric Nephro-Urology. Progress in Pediatric Urology, 80-93, 1, 1998.
 

Awards & Honors
  • Abstracts selected for Henry Wagner’s highlights lecture in Society of Nuclear Medicine, 2002.
  • Abstracts selected for Henry Wagner’s highlights lecture in Society of Nuclear Medicine, 2003.