School of Medicine

Wayne State University School of Medicine

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Paula Dore-Duffy
Title
Professor of Neurology; Chief, Neuroimmunology, Associate in Immunology/Microbiology
Phone
(313) 577-1126
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Paula Dore-Duffy, Ph.D. has been Professor of Neurology and Chief of the Division of Neuroimmunology since 1988. She was previously Associate Professor of Neurology and Director of the University of Connecticut MS Center. Dr. Dore-Duffy is Deputy Editor of the Journal of Neurological Sciences and currently sits on the editorial board of a number of other prestigious journals.

Dr. Dore-Duffy’s research interests fall within two main areas: 1) neuroimmunology of the CNS disorders, and 2) the physiology of the blood brain barrier (BBB) and the role played by the BBB in neurological diseases. Dr. Dore-Duffy developed techniques to isolate the CNS vascular pericyte, an integral cellular constituent of the neurovascular unit; she is considered one of the leading experts in this field. Her laboratory has recently identified this cell as an adult multipotent stem cell. Pericyte-related research projects include the role of pericytes in stress responses, brain tumors, and angiogenesis. Dr. Dore-Duffy has been funded throughout her career by the National Multiple Sclerosis Society, the National Institutes of Health, the Kroc Foundation, various pharmaceutical companies, and private philanthropy.

Undergraduate
Simmons College, Boston, Massachusetts, B.S. with honors, 1972
Graduate
Louisiana State University School of Medicine, Ph.D., 1976
Fellowships

University of Connecticut School of Medicine, 1976-1978

Prior Appointments

Assistant Professor of Neurology & Medicine, University of Connecticut Health Center, Farmington, Connecticut, 1979-1982

Associate Professor of Neurology & Medicine, University of Connecticut Health Center, Farmington, Connecticut, 1982-1988

Interests

Multiple sclerosis, inflammation, blood brain barrier, pericytes, hypoxia, vascular stroke, traumatic brain injury

Publications

Dore-Duffy, P., Balabanov, R, Beaumont, T. Katar, M. The CNS response to Low Oxygen: Synthesis of Cyclopentenone Prostaglandins of the J-series. Microvascular Res 69:79-88, 2005.

Katychev, A., Wang, X., Dore-Duffy, P. Characterization of CNS microvascular pericytes and endothelial cells exhibit multipotential stem cell activity. J. Cereb Blood Flow Metab 26:613-624, 2006.

Dore-Duffy, P and LaManna, JC. Physiologic angiodynamics in the brain. Antioxid Redox Signal 9: 1363-1371, 2007.

Dore-Duffy, P., Wang, X., Mehedi, A., and Rafols, J. Differential expression of capillary VEGF isoforms following traumatic brain injury. Neurological Res. 29: 395-403, 2007.

Dore-Duffy, P. Pericytes: Pluripotent gatekeepers of the blood brain barrier. Current Pharmaceutical Design. 14: 1581-1593, 2008.

Dore-Duffy P, Wencel M, Katyshev V, Cleary K. Chronic mild hypoxia ameliorates chronic inflammatory activity in myelin oligodendrocyte glycoprotein (MOG) peptide-induced experimental autoimmune encephalomyelitis (EAE). Adv Exp Med Biol 701:165-73, 2011.
 
Dore-Duffy P, Mehedi A, Wang X, Trotter R, Gow A. Immortalized CNS pericytes are quiescent smooth muscle actin-negative and pluripotent: endothelial trophic signals increase the rate of differentiation. J Microvasc Res 82 (1):18-27, 2011. 
 
Dore-Duffy P, Wang S, Mehedi A, Katyshev V, Cleary K, Tapper A, Reynolds C, Ding Y, Zhan P, Rafols J. Pericyte-mediated vasoconstriction underlies TBI-induced hypoperfusion. Neurol Res 33 (2):176-86, 2011.
 
Katyshev V, Dore-Duffy P. Pericyte coculture models to study astrocyte, pericyte, and endothelial cell interactions. Methods Mol Biol 2012:814:467-81.

 

Awards & Honors
  • Deputy Editor for the Journal of the Neurological Sciences 1998-2012
  • Serves on the editorial boards of Journal of Microvascular Research, Clinical Neuropharmacology, and the Open Circulation and Vascular Journal
  • 2008 Academy of Scholars – Wayne State University
  • 2007 Excellence in Research Award-Wayne State University School of Medicine
  • 1996 Charles Gershenson Distinguished Faculty Fellow, Wayne State University
  • 1993 Award for Dedication to MS Research, Multiple Sclerosis Society
  • 1985 Kroc Foundation Endowment $50,000 to establish a yearly MS Symposium on Multiple Sclerosis, University of Connecticut Health Center
Other Information

New research funding awarded in 2011

“Loss of Metabolic Homeostasis in the Brain of Patients with Multiple Sclerosis.” Sponsor: FCMSC/BAYER. Paula Dore-Duffy, PI.

“Endothelin and Traumatic Brain Injury: Implications for Advancement TBI Therapies.” Sponsor: Veterans Administration. Jose Rafols, PI, Paula Dore-Duffy, co-PI.

 “Clazosentan: a Novel Treatment for Traumatic Brain Injury.” Sponsor: NIH. Christian Kreipke, PI, Paula Dore-Duffy, co-PI.