School of Medicine

Wayne State University School of Medicine

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Maria Bykhovskaia
Professor of Neurology

Maria Bykhovskaia, PhD is a Professor of Neurology who joined  Wayne State University in 2015. She has a vast interest in the field of neuroscience with research interests in synaptic vesicle cycling and plasticity. 

Ph.D., 1992; Russian Academy of Sciences, St. Petersburg

 Bykhovskaia M. Calcium binding promotes conformational flexibility of neuronal Ca2+ sensor Synaptotagmin. 2015. Biophys. J. 108:2507-20.


Fortoul N. P. Singh, C.-Y. Hui, M. Bykhovskaia, and A. Jagota. 201.5 Coarse-Grained Model of SNARE Mediated Docking. Biophys. J., 108:2258-69.


Liu T, Singh P, Jenkins JT, Jagota A, Bykhovskaia M, Hui CY. A continuum model of docking of synaptic vesicle to plasma membrane. J R Soc Interface. 2015 Jan 6;12(102):20141119.


Vasin A., L. Zueva, C.Torrez, D.Volfson, J.T. Littleton, and M.Bykhovskaia. 2014. Synapsin regulates activity-dependent outgrowth of synaptic boutons at the Drosophila neuromuscular junction. J. Neurosci. 34 :10554-63.


Feliciano P., R. Andrade, and M. Bykhovskaia. 2013. Synapsin II and Rab3a cooperate in the regulation of epileptic and synaptic activity at in the CA1 region of the hippocampus synapses. J. Neurosci. 33:18319-30.


Bykhovskaia M., A. Jagota, A. Gonzales, A. Vasin, and J.T. Littleton. 2013. Interaction of the complexin accessory helix with the C-terminus of the SNARE complex:  molecular dynamics model of the fusion clamp. Biophys. J. 105:679-90.


Maldonado C., Alicea D. Gonzalez M. Bykhovskaia M. Marie B. 2012. RNA editing regulates synaptic structure and function. Mol. Cell Neurosci. 52:173-80.


Long R, C.Y. Hui, A.Jagota, and M.Bykhovskaia. 2012. Adhession energy can regulate fusion and stabiliza partially fused states. J. R. Soc. Interface.  9(72):1555-67


Bykhovskaia M. 2011. Synapsin regulation of vesicle organization and functional pools. Semin. Cell Dev. Biol. 22(4):387-92


Coleman W.L. and M. Bykhovskaia. 2010. Cooperative regulation of neurotransmitter release by Rab3a and synapsin II. Mol. Cell. Neurosci. 44:190-200.


Akbergenova Y. and M. Bykhovskaia. 2010. Synapsin regulates vesicle organization and activity-dependent recycling at Drosophila motor boutons. Neuroscience. 170:441-452


Coleman WL, Bykhovskaia M. 2009. Rab3a-mediated vesicle recruitment regulates short-term plasticity at the mouse diaphragm synapse. Mol Cell Neurosci 41: 286-296.


Akbergenova Y, Bykhovskaia M. 2009. Stimulation-induced formation of the reserve pool of vesicles in Drosophila motor boutons. J Neurophysiol 101: 2423-2433.


Coleman WL, Bykhovskaia M. 2009. Synapsin I accelerates the kinetics of neurotransmitter release in mouse motor terminals. Synapse 63: 531-533.


Akbergenova Y, Bykhovskaia M. 2009. Enhancement of the endosomal endocytic pathway increases quantal size. Mol Cell Neurosci 40: 199-206.


Coleman WL, Bill CA, Simsek-Duran F, Lonart G, Samigullin D, Bykhovskaia M. 2008. Synapsin II and calcium regulate vesicle docking and the cross-talk between vesicle pools at the mouse motor terminals. J Physiol 586: 4649-4673.


Bykhovskaia M. 2008. Making quantal analysis more convinient, fast and accurate: User friendly software QUANTAN. J. Neurosci. Methods. 168:500-513  


Akbergenova Y. and M. Bykhovskaia. 2007. Synapsin maintains the reserve vesicle pool and spatial segregation of the recycling pool in Drosophila motor boutons. Brain Research 1178:52-64


Coleman W.L., C.A.Bill, and M. Bykhovskaia. 2007. Rab3a deletion reduces vesicle docking and transmitter release at the mouse diaphragm synapse. Neuroscience 148:1-6.


Bykhovskaia M. 2007. Recruitment of presynaptic vesicles and facilitation of transmitter release. Neurocomputing 70:1689-1694


Kapitsky S., L. Zueva, Y.Akbergenova, and M. Bykhovskaia. 2005. Recruitment of synapses in neurosecretory process during long-term facilitation at the lobster neuromuscular junction. Neuroscience. 134:1261-1272.


Samigullin D., C.A.Bill, W.L Coleman, and M. Bykhovskaia. 2004. Regulation of transmitter release by synapsin II in mouse motor terminals. J. Physiol. Lond. 561:149-158.